| Title: | Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia |
| Journal: | Intelligence |
| Published: | 1 Sep 2021 |
| DOI: | https://doi.org/10.1016/j.intell.2021.101565 |
Publication 10043
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Abstract
We generated two polygenic scores, one capturing verbal and the other spatial aspects of cognitive ability, using UK Biobank data and studied their effects on various diseases and other traits in the Icelandic population. The score tagging spatial ability associated with higher body mass index (β = 0.032, p = 3.2 × 10−13), but lower risk of schizophrenia (OR = 0.82, p = 8.8 × 10−9) and other mental disorders. Furthermore, it associated with less openness, a personality trait reflecting curiosity and creativity (β = −0.023, p = 1.3 × 10−4). Conversely, the score tagging verbal ability associated with lower body mass index (β = −0.023, p = 1.6 × 10−7) and more openness (β = 0.045, p = 3.5 × 10−14), but did not associate with risk of schizophrenia (OR = 0.97, p = 0.42). Furthermore, applying genomic structural equation modeling, we observed that the genetic component of verbal ability associated positively with the genetic component of schizophrenia after conditioning on the g factor (b g = 0.193, p = 5.4 × 10−4). Thus, at the genetic level, verbal and spatial ability exhibit contrasting associations with indicators of mental and physical health, as well as with personality.</p>
29 Authors
- Gudrun A. Jonsdottir
- Gudmundur Einarsson
- Gudmar Thorleifsson
- Sigurdur H. Magnusson
- Arni F. Gunnarsson
- Michael L. Frigge
- Rosa S. Gisladottir
- Unnur Unnsteinsdottir
- Bjarni Gunnarsson
- G. Bragi Walters
- Valgerdur Steinthorsdottir
- Anna Helgadottir
- Ingileif Jonsdottir
- Thorsteinn Gislason
- Haraldur S. Thorsteinsson
- Engilbert Sigurdsson
- Magnus Haraldsson
- Emil L. Sigurdsson
- Ragnar Bjarnason
- Isleifur Olafsson
- Gudmundur Thorgeirsson
- Patrick Sulem
- Hilma Holm
- Unnur Thorsteinsdottir
- Daniel F. Gudbjartsson
- Gyda Bjornsdottir
- Thorgeir E. Thorgeirsson
- Hreinn Stefansson
- Kari Stefansson
1 Application
| Application ID | Title |
|---|---|
| 24898 | Genetics of lumbar disc disease and associated sciatica |
Enabling scientific discoveries that improve human health