| Title: | Genetic and phenotypic analysis of the causal relationship between aging and COVID-19 |
| Journal: | Communications Medicine |
| Published: | 5 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35602207/ |
| DOI: | https://doi.org/10.1038/s43856-021-00033-z |
| URL: | https://www.nature.com/articles/s43856-021-00033-z.pdf |
Publication 10409
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundEpidemiological studies revealed that the elderly and those with comorbidities are most affected by COVID-19, but it is important to investigate shared genetic mechanisms between COVID-19 risk and aging.MethodsWe conducted a multi-instrument Mendelian Randomization analysis of multiple lifespan-related traits and COVID-19. Aging clock models were applied to the subjects with different COVID-19 conditions in the UK-Biobank cohort. We performed a bivariate genomic scan for age-related COVID-19 and Mendelian Randomization analysis of 389 immune cell traits to investigate their effect on lifespan and COVID-19 risk.ResultsWe show that the genetic variation that supports longer life is significantly associated with the lower risk of COVID-19 infection and hospitalization. The odds ratio is 0.31 (P = 9.7 × 10−6) and 0.46 (P = 3.3 × 10−4), respectively, per additional 10 years of life. We detect an association between biological age acceleration and future incidence and severity of COVID-19 infection. Genetic profiling of age-related COVID-19 infection indicates key contributions of Notch signaling and immune system development. We reveal a negative correlation between the effects of immune cell traits on lifespan and COVID-19 risk. We find that lower B-cell CD19 levels are indicative of an increased risk of COVID-19 and decreased life expectancy, which is further validated by COVID-19 clinical data.ConclusionsOur analysis suggests that the factors that accelerate aging lead to an increased COVID-19 risk and point to the importance of Notch signaling and B cells in both. Interventions that target these factors to reduce biological age may reduce the risk of COVID-19.</p>
8 Authors
- Kejun Ying
- Ranran Zhai
- Timothy V. Pyrkov
- Anastasia V. Shindyapina
- Marco Mariotti
- Peter O. Fedichev
- Xia Shen
- Vadim N. Gladyshev
1 Application
| Application ID | Title |
|---|---|
| 21988 | The project of Quantum Pharmacutical company (q-pharm.com) |
Enabling scientific discoveries that improve human health