| Title: | A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo |
| Journal: | Communications Biology |
| Published: | 7 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34620984/ |
| DOI: | https://doi.org/10.1038/s42003-021-02673-2 |
| URL: | https://www.nature.com/articles/s42003-021-02673-2.pdf |
Publication 10413
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Abstract
Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (Ncases = 48,072, Ncontrols = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant vertigo variants were associated with hearing loss and only one was associated with age-related hearing impairment. Our results uncovered sequence variants associating with vertigo in a genome-wide association study and implicated genes with known roles in inner ear development, maintenance, and disease.</p>
31 Authors
- Astros Th. Skuladottir
- Gyda Bjornsdottir
- Muhammad Sulaman Nawaz
- Hannes Petersen
- Solvi Rognvaldsson
- Kristjan Helgi Swerford Moore
- Pall I. Olafsson
- Sigurður H. Magnusson
- Anna Bjornsdottir
- Olafur A. Sveinsson
- Gudrun R. Sigurdardottir
- Saedis Saevarsdottir
- Erna V. Ivarsdottir
- Lilja Stefansdottir
- Bjarni Gunnarsson
- Joseph B. Muhlestein
- Kirk U. Knowlton
- David A. Jones
- Lincoln D. Nadauld
- Annette M. Hartmann
- Dan Rujescu
- Michael Strupp
- G. Bragi Walters
- Thorgeir E. Thorgeirsson
- Ingileif Jonsdottir
- Hilma Holm
- Gudmar Thorleifsson
- Daniel F. Gudbjartsson
- Patrick Sulem
- Hreinn Stefansson
- Kari Stefansson
1 Application
| Application ID | Title |
|---|---|
| 24898 | Genetics of lumbar disc disease and associated sciatica |
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