| Title: | Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics |
| Journal: | Nature Communications |
| Published: | 21 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34675202/ |
| DOI: | https://doi.org/10.1038/s41467-021-25731-z |
| URL: | https://www.nature.com/articles/s41467-021-25731-z.pdf |
Publication 10423
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Abstract
Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same target. Here we apply MR to prioritize drug targets for their causal relevance for coronary heart disease (CHD). The targets are further prioritized using independent replication, co-localization, protein expression profiles and data from the British National Formulary and clinicaltrials.gov. Out of the 341 drug targets identified through their association with blood lipids (HDL-C, LDL-C and triglycerides), we robustly prioritize 30 targets that might elicit beneficial effects in the prevention or treatment of CHD, including NPC1L1 and PCSK9, the targets of drugs used in CHD prevention. We discuss how this approach can be generalized to other targets, disease biomarkers and endpoints to help prioritize and validate targets during the drug development process.</p>
21 Authors
- María Gordillo-Marañón
- Magdalena Zwierzyna
- Pimphen Charoen
- Fotios Drenos
- Sandesh Chopade
- Tina Shah
- Jorgen Engmann
- Nishi Chaturvedi
- Olia Papacosta
- Goya Wannamethee
- Andrew Wong
- Reecha Sofat
- Mika Kivimaki
- Jackie F. Price
- Alun D. Hughes
- Tom R. Gaunt
- Deborah A. Lawlor
- Anna Gaulton
- Aroon D. Hingorani
- Amand F. Schmidt
- Chris Finan
1 Application
| Application ID | Title |
|---|---|
| 12113 | Harnessing associations of genetic and phenotypic traits for drug target validation, Ref: 12113. |
Enabling scientific discoveries that improve human health