| Title: | Association of MAFLD with end-stage kidney disease: a prospective study of 337,783 UK Biobank participants |
| Journal: | Hepatology International |
| Published: | 21 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36809487/ |
| DOI: | https://doi.org/10.1007/s12072-023-10486-0 |
Publication 11113
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Abstract
IntroductionMetabolic dysfunction-associated fatty liver (MAFLD) has been found to be associated with the prevalence of chronic kidney disease (CKD). However, it is unknown whether MAFLD is associated with CKD development and the incidence of end-stage kidney disease (ESKD). We aimed to clarify the association between MAFLD and incident ESKD in the prospective UK Biobank cohort.MethodsWe analyzed the data of 337,783 UK Biobank participants and relative risks for the ESKD were calculated by using the Cox regression analysis.ResultsAmong 337,783 participants over a median duration of 12.8 years follow-up, a total of 618 ESKD cases were diagnosed. Participants with MAFLD were twice likely to develop ESKD (hazard ratio [HR] 2.03, 95% confidence interval [CI] 1.68-2.46, p < 0.001). The association of MAFLD with ESKD risk remained significant in both non-CKD and CKD participants. Our results also showed that there were graded associations between liver fibrosis scores and the risk of ESKD in MAFLD cases. Compared to non-MAFLD individuals, the adjusted HRs for incident ESKD in MAFLD patients with increasing levels of NAFLD fibrosis score were 1.23 (95% CI 0.96-1.58), 2.45 (1.98-3.03) and 7.67 (5.48-10.73), respectively. Furthermore, the risking alleles of PNPLA3 rs738409, TM6SF2 rs58542926, GCKR rs1260326 and MBOAT7 rs641738 amplified the MAFLD effect on ESKD risk. In conclusion, MAFLD is associated with incident ESKD.ConclusionMAFLD may help identify the subjects at high risk of ESKD development and MAFLD interventions should be encouraged to slow down CKD progression.</p>
5 Authors
- Shen Chen
- Juan Pang
- Rong Huang
- Hongliang Xue
- Xu Chen
1 Application
| Application ID | Title |
|---|---|
| 76670 | Nutritional and lifestyle influences on the risk and outcome of different metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes |
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