| Title: | Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study |
| Journal: | Investigative Ophthalmology & Visual Science |
| Published: | 3 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36867133/ |
| DOI: | https://doi.org/10.1167/iovs.64.3.11 |
Publication 11170
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Purpose: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma.</p>
Methods: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data.</p>
Results: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 µm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 µm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-µm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 ± 0.46 µm/y versus -0.62 ± 0.55 µm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 µm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 µm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 µm/SD; 95% CI, 0.47-1.14; P < 0.001).</p>
Conclusions: These results highlight the potential neuroprotective benefits of exercise on the human retina.</p>
25 Authors
- Ella C Berry
- Henry N Marshall
- Sean Mullany
- Santiago Diaz Torres
- Joshua Schmidt
- Daniel Thomson
- Lachlan S W Knight
- Georgina L Hollitt
- Ayub Qassim
- Bronwyn Ridge
- Angela Schulz
- Mark M Hassall
- Thi Thi Nguyen
- Stewart Lake
- Richard A Mills
- Ashish Agar
- Anna Galanopoulos
- John Landers
- Paul R Healey
- Stuart L Graham
- Alex W Hewitt
- Stuart MacGregor
- Robert J Casson
- Owen M Siggs
- Jamie E Craig
1 Application
| Application ID | Title |
|---|---|
| 25331 | Gene mapping and genetic correlation across complex traits |
Enabling scientific discoveries that improve human health