| Title: | Association of blood pressure with incident diabetic microvascular complications among diabetic patients: Longitudinal findings from the UK Biobank |
| Journal: | Journal of Global Health |
| Published: | 24 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36960684/ |
| DOI: | https://doi.org/10.7189/jogh.13.04027 |
| URL: | https://jogh.org/wp-content/uploads/2023/03/jogh-13-04027.pdf |
Publication 11234
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Abstract
Background: Evidence suggests a correlation of blood pressure (BP) level with presence of diabetic microvascular complications (DMCs), but the effect of BP on DMCs incidence is not well-established. We aimed to explore the associations between BP and DMCs (diabetic retinopathy, diabetic kidney disease, and diabetic neuropathy) risk in participants with diabetes.</p>
Methods: This study included 23 030 participants, free of any DMCs at baseline, from the UK Biobank. We applied multivariable-adjusted Cox regression models to estimate BP-DMCs association and constructed BP genetic risk scores (GRSs) to test their association with DMCs phenotypes. Differences in incidences of DMCs were also compared between the 2017 ACC/AHA and JNC 7 guidelines (traditional criteria) of hypertension.</p>
Results: Compared to systolic blood pressure (SBP)<120 mm Hg, participants with SBP≥160 mm Hg had a hazard ratio (HR) of 1.50 (95% confidence interval (CI) = 1.09, 2.06) for DMCs. Similarly, DMCs risk increased by 9% for every 10 mm Hg of higher SBP at baseline (95% CI = 1.04, 1.13). The highest tercile SBP GRS was associated with 32% higher DMCs risk (95% CI = 1.11, 1.56) compared to the lowest tercile. We found no significant differences in DMCs incidence between JNC 7 and 2017 ACC/AHA guidelines.</p>
Conclusions: Genetic and epidemiological evidence suggests participants with higher SBP had an increased risk of DMCs, but hypertension defined by 2017 ACC/AHA guidelines may not impact DMCs incidence compared with JNC 7 criteria, contributing to the care and prevention of DMCs.</p>
8 Authors
- Cong Li
- Honghua Yu
- Zhuoting Zhu
- Xianwen Shang
- Yu Huang
- Charumathi Sabanayagam
- Xiaohong Yang
- Lei Liu
1 Application
| Application ID | Title |
|---|---|
| 62489 | The eye and the heart |
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