| Title: | Association between walking pace and incident type 2 diabetes by adiposity level: A prospective cohort study from the UK Biobank |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 3 Apr 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36951683/ |
| DOI: | https://doi.org/10.1111/dom.15053 |
| URL: | https://eprints.gla.ac.uk/294545/2/294545.pdf |
Publication 11282
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Abstract
AIMS: To investigate the combined association of adiposity and walking pace with incident type 2 diabetes.</p>
METHODS: We undertook a prospective cohort study in 194 304 White-European participants (mean age 56.5 years, 55.9% women). Participants' walking pace was self-reported as brisk, average or slow. Adiposity measures included body mass index (BMI), waist circumference (WC) and body fat percentage (BF%). Associations were investigated using Cox proportional hazard models, with a 2-year landmark analysis. A four-way decomposition analysis was used for mediation and additive interaction.</p>
RESULTS: The median (interquartile range) follow-up was 5.4 (4.8-6.3) years. During the follow-up period, 4564 participants developed type 2 diabetes. Compared to brisk-walking participants with normal BMI, those with obesity who walked briskly were at an approximately 10- to 12-fold higher risk of type 2 diabetes (hazard ratio [HR] 9.64, 95% confidence interval [CI] 7.24-12.84, in women; HR 11.91, 95% CI 8.80-16.12, in men), whereas those with obesity and walked slowly had an approximately 12- to 15-fold higher risk (HR 12.68, 95% CI 9.62-16.71, in women; HR 15.41, 95% CI 11.27-21.06, in men). There was evidence of an additive interaction between WC and BF% and walking pace among women, explaining 17.8% and 47.9% excess risk respectively. Obesity mediated the association in women and men, accounting for 60.1% and 44.9%, respectively.</p>
CONCLUSIONS: Slow walking pace is a risk factor for type 2 diabetes independent of adiposity. Promoting brisk walking as well as weight management might be an effective type 2 diabetes prevention strategy given their synergistic effects.</p>
13 Authors
- Jirapitcha Boonpor
- Solange Parra-Soto
- Jasunella Gore
- Atefeh Talebi
- Nathan Lynskey
- Andrea Raisi
- Paul Welsh
- Naveed Sattar
- Jill P. Pell
- Jason M. R. Gill
- Stuart R. Gray
- Frederick K. Ho
- Carlos A. Celis-Morales
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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