| Title: | Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study |
| Journal: | Alzheimer's & Dementia |
| Published: | 8 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37157186/ |
| DOI: | https://doi.org/10.1002/alz.13122 |
Publication 11423
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Abstract
INTRODUCTION: The association of age at stroke onset with dementia and the role of post-stroke lifestyle on dementia risk remains unclear.</p>
METHODS: We leveraged data of 496,251 dementia-free participants from UK Biobank and explored the relationship between age at stroke onset and incident dementia. Among 8328 participants with stroke history, we further investigated the association of a healthy lifestyle with risk of dementia.</p>
RESULTS: Participants with stroke history had a higher risk of dementia (hazard ratio [HR], 2.02). The association was stronger among participants with stroke onset at a younger age (≤50: HR, 2.63) compared with those at the age > 50 years (50-60: HR, 2.17; ≥60: HR, 1.58). Among participants with stroke history, a favorable lifestyle was associated with a lower risk of incident dementia.</p>
DISCUSSION: Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.</p>
8 Authors
- Wansi Zhong
- Hui Chen
- Xiaoxian Gong
- Lusha Tong
- Xin Xu
- Geng Zong
- Changzheng Yuan
- Min Lou
1 Application
| Application ID | Title |
|---|---|
| 55005 | Common risk factors and mechanisms in cardiometabolic diseases and neurodegenerative diseases |
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