| Title: | Adiposity and sex-specific cancer risk |
| Journal: | Cancer Cell |
| Published: | 1 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37311415/ |
| DOI: | https://doi.org/10.1016/j.ccell.2023.05.010 |
| URL: | http://www.cell.com/article/S1535610823001770/pdf |
Publication 11526
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.</p>
6 Authors
- Mathias Rask-Andersen
- Emma Ivansson
- Julia Höglund
- Weronica E Ek
- Torgny Karlsson
- Åsa Johansson
1 Application
| Application ID | Title |
|---|---|
| 15152 | Interaction between diet, food preference and lifestyle with genetic factors influencing body mass, body adiposity and obesity |
Enabling scientific discoveries that improve human health