| Title: | Association between long-term exposure to wildfire-related PM2.5 and mortality: A longitudinal analysis of the UK Biobank |
| Journal: | Journal of Hazardous Materials |
| Published: | 8 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37307727/ |
| DOI: | https://doi.org/10.1016/j.jhazmat.2023.131779 |
Publication 11540
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Little is known about the associations between long-term exposure to wildfire-related fine particulate matter (PM2.5) and mortality. We aimed to explore theses associations using the data from the UK Biobank cohort. Long-term wildfire-related PM2.5 exposure was defined as the 3-year cumulative concentrations of wildfire-related PM2.5 within a 10-km buffer surrounding the residential address for each individual. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using the time-varying Cox regression model. We included 492,394 participants aged between 38 and 73 years. We found that after adjusting for potential covariates, a 10 μg/m3 increase of wildfire-related PM2.5 exposure was associated with a 0.4% higher risk of all-cause mortality (HR = 1.004 [95% CI: 1.001, 1.006]) and nonaccidental mortality (HR = 1.004 [95% CI: 1.002, 1.006]), and a 0.5% higher risk of neoplasm mortality (HR = 1.005 [95% CI: 1.002, 1.008]). However, no significant associations were observed between wildfire-related PM2.5 exposure and mortality from cardiovascular, respiratory, and mental diseases. Additionally, no significant modification effects of a series of modifiers were observed. Targeted health protection strategies should be adopted in response to wildfire-related PM2.5 exposure, in order to reduce the risk of premature mortality.</p>
14 Authors
- Yuan Gao
- Wenzhong Huang
- Rongbin Xu
- Danijela Gasevic
- Yanming Liu
- Wenhua Yu
- Pei Yu
- Xu Yue
- Guowei Zhou
- Yan Zhang
- Hong Liu
- Jiangning Song
- Yuming Guo
- Shanshan Li
Enabling scientific discoveries that improve human health