| Title: | Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis |
| Journal: | Communications Biology |
| Published: | 4 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37402774/ |
| DOI: | https://doi.org/10.1038/s42003-023-04869-0 |
| URL: | https://www.nature.com/articles/s42003-023-04869-0.pdf |
Publication 11616
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Abstract
Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~ 43,800) of SK-BMD, identifying 59 loci, collectively explaining 12.5% of the trait variance. Association signals cluster within gene-sets involved in skeletal development and osteoporosis. Among the four novel loci (ZIC1, PRKAR1A, AZIN1/ATP6V1C1, GLRX3), there are factors implicated in intramembranous ossification and as we show, inherent to craniosynostosis processes. Functional follow-up in zebrafish confirms the importance of ZIC1 on cranial suture patterning. Likewise, we observe abnormal cranial bone initiation that culminates in ectopic sutures and reduced BMD in mosaic atp6v1c1 knockouts. Mosaic prkar1a knockouts present asymmetric bone growth and, conversely, elevated BMD. In light of this evidence linking SK-BMD loci to craniofacial abnormalities, our study provides new insight into the pathophysiology, diagnosis and treatment of skeletal diseases.</p>
58 Authors
- Carolina Medina-Gomez
- Benjamin H. Mullin
- Alessandra Chesi
- Vid Prijatelj
- John P. Kemp
- Chen Shochat-Carvalho
- Katerina Trajanoska
- Carol Wang
- Raimo Joro
- Tavia E. Evans
- Katharina E. Schraut
- Ruifang Li-Gao
- Tarunveer S. Ahluwalia
- M. Carola Zillikens
- Kun Zhu
- Dennis O. Mook-Kanamori
- Daniel S. Evans
- Maria Nethander
- Maria J. Knol
- Gudmar Thorleifsson
- Ivana Prokic
- Babette Zemel
- Linda Broer
- Fiona E. McGuigan
- Natasja M. van Schoor
- Sjur Reppe
- Mikolaj A. Pawlak
- Stuart H. Ralston
- Nathalie van der Velde
- Mattias Lorentzon
- Kari Stefansson
- Hieab H. H. Adams
- Scott G. Wilson
- M. Arfan Ikram
- John P. Walsh
- Timo A. Lakka
- Kaare M. Gautvik
- James F. Wilson
- Eric S. Orwoll
- Cornelia M. van Duijn
- Klaus Bønnelykke
- Andre G. Uitterlinden
- Unnur Styrkársdóttir
- Kristina E. Akesson
- Timothy D. Spector
- Jonathan H. Tobias
- Claes Ohlsson
- Janine F. Felix
- Hans Bisgaard
- Struan F. A. Grant
- J. Brent Richards
- David M. Evans
- Bram van der Eerden
- Jeroen van de Peppel
- Cheryl Ackert-Bicknell
- David Karasik
- Erika Kague
- Fernando Rivadeneira
1 Application
| Application ID | Title |
|---|---|
| 53641 | Determining the genetic and environmental aetiology of complex traits and diseases using existing and novel statistical methodologies |
Enabling scientific discoveries that improve human health