| Title: | Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 11 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38986027/ |
| DOI: | https://doi.org/10.1210/clinem/dgae481 |
| URL: | https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae481/58689210/dgae481.pdf |
Publication 11668
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Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with adverse clinical outcomes that may differ according to PCOS phenotype.</p>
METHODS: Using UK Biobank data, we compared the incidence of type 2 diabetes (T2D), metabolic dysfunction associated steatotic liver disease, cardiovascular disease (CVD), hormone-dependent cancers, and dementia between PCOS participants and age- and body mass index-matched controls. We also compared multiorgan (liver, cardiac, and brain) magnetic resonance imaging (MRI) data and examined the impact of PCOS phenotype (hyperandrogenic and normoandrogenic) on these outcomes.</p>
RESULTS: We included 1008 women with PCOS (defined by diagnostic codes, self-reported diagnoses, or clinical/biochemical features of hyperandrogenism and a/oligoCmenorrhoea) and 5017 matched controls (5:1 ratio); median age, 61 years, body mass index, 28.4 kg/m². Adjusted Cox proportional hazard modeling demonstrated PCOS participants had greater incident T2D [hazard ratio (HR) 1.47; 95% confidence interval (CI), 1.11-1.95] and all-cause CVD (1.76; 1.35-2.30). No between-group differences existed for cancers or dementia. Liver MRI confirmed more PCOS participants had hepatic steatosis (proton density fat fraction >5.5%: 35.9 vs 23.9%; P = .02) and higher fibroinflammation (corrected T1 721.4 vs 701.5 ms; P = <.01) vs controls. No between-group difference existed for cardiac (biventricular/atrial structure and function) or brain (grey and white matter volumes) imaging. Normoandrogenic (but not hyperandrogenic) PCOS participants had greater incident all-cause CVD (1.82; 1.29-2.56) while hyperandrogenic (but not normoandrogenic) PCOS participants were more likely to have hepatic steatosis (8.96 vs 6.04 vs 5.23%; P = .03) with greater fibroinflammation (776.3 vs 707.7 vs 701.9 ms; P=<.01).</p>
CONCLUSION: Cardiometabolic disease may be increased in PCOS patients with a disease phenotype-specific pattern.</p>
15 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Case-Control Studies
- Dementia
- Diabetes Mellitus, Type 2
- Fatty Liver
- Female
- Humans
- Incidence
- Magnetic Resonance Imaging
- Middle Aged
- Polycystic Ovary Syndrome
- Risk Factors
- United Kingdom
13 Authors
- Alex E Henney
- Conor S Gillespiec
- Jonathan Y M Lai
- Pieta Schofield
- David R Riley
- Rishi Caleyachetty
- Thomas M Barber
- Alexander D Miras
- Laurence J Dobbie
- David M Hughes
- Uazman Alam
- Theresa J Hydes
- Daniel J Cuthbertson
1 Application
| Application ID | Title |
|---|---|
| 74170 | Cardio-metabolic risk, body composition and cardio-metabolic events in women with Polycystic Ovary Syndrome (PCOS) |
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