| Title: | Prospective cohort studies underscore the association of abnormal glycemic measures with all-cause and cause-specific mortalities |
| Journal: | iScience |
| Published: | 8 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39021808/ |
| DOI: | https://doi.org/10.1016/j.isci.2024.110233 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253504 |
Publication 11749
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Abstract
The role of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and triglyceride-glucose index (TyG index) in predicting all-cause and cause-specific mortalities remains elusive. This study included 384,420 adults from the Shanghai cohort and the UK Biobank (UKB) cohort. After multivariable adjustment in the Cox models, FPG ≥7.0 mmol/L or HbA1c ≥ 6.5% increased the risk of all-cause mortality, FPG ≥5.6 mmol/L or HbA1c ≥ 6.5% increased CVD-related mortality, and higher or lower TyG index increased all-cause and CVD-related mortalities in the Shanghai cohort; FPG ≥5.6 mmol/L, HbA1c ≥ 5.7%, TyG index <8.31 or ≥9.08 increased the risks of all-cause, CVD-related, and cancer-related mortalities in the UKB cohort. FPG or HbA1c increased the discrimination of the conventional risk model in predicting all-cause and CVD-related mortalities in both cohorts. Thus, increased levels of FPG and HbA1c and U-shaped TyG index increase the risks of all-cause especially CVD-related mortalities.</p>
11 Authors
- Juzhong Ke
- Xiaonan Ruan
- Wenbin Liu
- Xiaolin Liu
- Kang Wu
- Hua Qiu
- Xiaonan Wang
- Yibo Ding
- Xiaojie Tan
- Zhitao Li
- Guangwen Cao
1 Application
| Application ID | Title |
|---|---|
| 101971 | Effects of physical activity, environmental exposure, and multilevel biomarkers including genetic predisposition and inflammatory markers on the cancer occurrence and all-cause / cancer mortalities |
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