| Title: | Sleep, physical activity, and sedentary behaviors in relation to overall cancer and site-specific cancer risk: A prospective cohort study |
| Journal: | iScience |
| Published: | 9 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38974470/ |
| DOI: | https://doi.org/10.1016/j.isci.2024.109931 |
Publication 12119
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Abstract
Large prospective studies are required to better elucidate the associations of physical activity, sedentary behaviors (SBs), and sleep with overall cancer and site-specific cancer risk, accounting for the interactions with genetic predisposition. The study included 360,271 individuals in UK Biobank. After a median follow-up of 12.52 years, we found higher total physical activity (TPA) level and higher sleep scores were related to reduced risk of cancer while higher SB level showed a positive association with cancer. Compared with high TPA-healthy sleep group and low SB-healthy sleep group, low TPA-poor sleep group and high SB-poor sleep group had the highest risk for overall cancer, breast cancer, and lung cancer. Adherence to a more active exercise pattern was associated with a lower risk of cancer irrespective of genetic risk. Our study suggests that improving the quality of sleep and developing physical activity habits might yield benefits in mitigating the cancer risk.</p>
11 Authors
- Rongqi Zhang
- Ying Lu
- Zilong Bian
- Siyun Zhou
- Liying Xu
- Fangyuan Jiang
- Shuai Yuan
- Xiao Tan
- Xiangjun Chen
- Yuan Ding
- Xue Li
1 Application
| Application ID | Title |
|---|---|
| 66354 | Investigating the genetic, environmental and clinical determinants and their interactions on cancer risk, and developing risk prediction and prognosis models for common cancer types |
Enabling scientific discoveries that improve human health