| Title: | Sleep duration, chronotype, health and lifestyle factors affect cognition: a UK Biobank cross-sectional study |
| Journal: | BMJ Public Health |
| Published: | 1 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40018197/ |
| DOI: | https://doi.org/10.1136/bmjph-2024-001000 |
| URL: | https://bmjpublichealth.bmj.com/content/2/1/e001000.full.pdf |
Publication 12170
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Abstract
Objective: To explore the nuanced relationship between sleep patterns, chronotype, quality and the influence of health and lifestyle factors on cognitive performance.</p>
Design setting participants: This cross-sectional analysis used ordinary least squares regression within the UK Biobank database, assessing 26 820 participants aged 53-86 years, categorised into two cohorts: Cohort 1 (10 067 participants, 56% female; completed all four cognitive tests of Fluid Intelligence/reasoning, Pairs Matching, Reaction Time and Prospective Memory) and Cohort 2 (16 753 participants, 56% female; completed only two cognitive assessments of Pairs Matching and Reaction Time).</p>
Exposures: Participant's self-reported sleep duration, chronotype and quality. Cognitive function was assessed through standardised computerised tests. The analysis was adjusted for demographic and comorbidity covariates.</p>
Main outcomes and measures: Cognitive performance scores were evaluated against sleep parameters and health and lifestyle factors including sex, age, vascular and cardiac conditions, diabetes, alcohol intake, smoking habits and body mass index.</p>
Results: The regression highlighted a positive association between normal sleep duration (7-9 hours) and cognitive scores in Cohort 1 (β=0.0567, 95% CI 0.0284 to 0.0851), while extended sleep duration negatively impacted scores across both cohorts (Cohort 1: β=-0.188, 95% CI -0.2938 to -0.0822; Cohort 2: β=-0.2619, 95% CI -0.3755 to -0.1482). Chronotype distinctions, particularly intermediate and evening types, were linked to superior cognitive function. Gender, age, angina, high blood pressure, diabetes, alcohol intake and smoking emerged as significant cognitive influencers.</p>
Conclusions and relevance: The study delineates a multifaceted and nuanced relationship between sleep variables, health and lifestyle factors in determining cognitive outcomes. These findings highlight the vital role of sleep quality on cognitive health.</p>
7 Authors
- Raha West
- Ryan Tak Chun Wong
- Ji-Eun Park
- Si Woo Lee
- Dinayinie Ekanayake Mudiyanselage
- Zhigang Liu
- Daqing Ma
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