| Title: | The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts |
| Journal: | Ophthalmology |
| Published: | 30 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35500606/ |
| DOI: | https://doi.org/10.1016/j.ophtha.2022.04.023 |
| Citations: | 18 (17 in last 2 years) as of 8 Aug 2024 |
Publication 12392
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
PURPOSE: Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP).</p>
DESIGN: Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts.</p>
PARTICIPANTS: We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009.</p>
METHODS: Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc).</p>
MAIN OUTCOME MEASURES: Corneal-compensated IOP.</p>
RESULTS: Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06-0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08-0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05-0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07-0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03-0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06-0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (-0.05 mmHg; 95% CI, -0.08 to -0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort (P = 0.30).</p>
CONCLUSIONS: Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature.</p>
11 Keywords
- Aged
- Cholesterol, HDL
- Cholesterol, LDL
- Cross-Sectional Studies
- Humans
- Intraocular Pressure
- Middle Aged
- Prospective Studies
- Risk Factors
- Triglycerides
- United Kingdom
92 Authors
- Kian M. Madjedi
- Kelsey V. Stuart
- Sharon Y.L. Chua
- Robert N. Luben
- Alasdair Warwick
- Louis R. Pasquale
- Jae H. Kang
- Janey L. Wiggs
- Marleen A.H. Lentjes
- Hugues Aschard
- Naveed Sattar
- Paul J. Foster
- Anthony P. Khawaja
- Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium
- Mark Chia
- Ron Do
- Alan Kastner
- Jihye Kim
- Giovanni Montesano
- Denize Atan
- Tariq Aslam
- Sarah A. Barman
- Jenny H. Barrett
- Paul Bishop
- Peter Blows
- Catey Bunce
- Roxana O. Carare
- Usha Chakravarthy
- Michelle Chan
- Sharon Y.L. Chua
- David P. Crabb
- Philippa M. Cumberland
- Alexander Day
- Parul Desai
- Bal Dhillon
- Andrew D. Dick
- Cathy Egan
- Sarah Ennis
- Paul Foster
- Marcus Fruttiger
- John E.J. Gallacher
- David F. Garway-Heath
- Jane Gibson
- Dan Gore
- Jeremy A. Guggenheim
- Chris J. Hammond
- Alison Hardcastle
- Simon P. Harding
- Ruth E. Hogg
- Pirro Hysi
- Pearse A. Keane
- Peng T. Khaw
- Anthony P. Khawaja
- Gerassimos Lascaratos
- Andrew J. Lotery
- Tom Macgillivray
- Sarah Mackie
- Keith Martin
- Michelle McGaughey
- Bernadette McGuinness
- Gareth J. McKay
- Martin McKibbin
- Danny Mitry
- Tony Moore
- James E. Morgan
- Zaynah A. Muthy
- Eoin O'Sullivan
- Chris G. Owen
- Praveen Patel
- Euan Paterson
- Tunde Peto
- Axel Petzold
- Jugnoo S. Rahi
- Alicja R. Rudnikca
- Jay Self
- Sobha Sivaprasad
- David Steel
- Irene Stratton
- Nicholas Strouthidis
- Cathie Sudlow
- Dhanes Thomas
- Emanuele Trucco
- Adnan Tufail
- Veronique Vitart
- Stephen A. Vernon
- Ananth C. Viswanathan
- Cathy Williams
- Katie Williams
- Jayne V. Woodside
- MaxM. Yates
- Jennifer Yip
- Yalin Zheng
2 Applications
| Application ID | Title |
|---|---|
| 2112 | Automated macular thickness measurements and association with potential risk factors and systemic disease |
| 36741 | Discovering the biological mechanisms underlying glaucoma and neurodegeneration by analysis of genetic and environmental determinants and associations with other systemic traits in the UK Biobank |
Enabling scientific discoveries that improve human health