| Title: | Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons |
| Journal: | Neurology |
| Published: | 25 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39052961/ |
| DOI: | https://doi.org/10.1212/wnl.0000000000209687 |
| URL: | https://ora.ox.ac.uk/objects/uuid:5698f840-23f7-4cbe-bbe0-b70119d92302/files/s9306t135b |
Publication 12779
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Abstract
OBJECTIVES: To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.</p>
METHODS: This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex.</p>
RESULTS: We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%-27%] first, 33% [27%-39%] repeat) and higher FA (18% [16%-20%] first, 22% [15%-28%] repeat), with a decrease in MD (9% [7%-11%] first, 10% [4%-16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%-17%] reduction in WMH progression and FA decline over time.</p>
DISCUSSION: This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline.</p>
14 Keywords
- Adult
- Aged
- Brain
- Cohort Studies
- Diffusion Tensor Imaging
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neuroimaging
- Prospective Studies
- Risk Factors
- White Matter
30 Authors
- Cyprien A Rivier
- Sanjula Singh
- Jasper Senff
- Reinier W Tack
- Sandro Marini
- Santiago Clocchiatti-Tuozzo
- Shufan Huo
- Daniela Renedo
- Keren Papier
- Megan Conroy
- Thomas J Littlejohns
- Zeina Chemali
- Christina Kourkoulis
- Seyedmehdi Payabvash
- Amy Newhouse
- M Brandon Westover
- Ronald M Lazar
- Aleksandra Pikula
- Sarah Ibrahim
- Virginia J Howard
- George Howard
- H Bart Brouwers
- Cornelia M Van Duijn
- Gregory Fricchione
- Rudolph E Tanzi
- Nirupama Yechoor
- Kevin N Sheth
- Christopher D Anderson
- Jonathan Rosand
- Guido J Falcone
1 Application
| Application ID | Title |
|---|---|
| 58743 | Genetic and non-genetic determinants of cardiovascular disease, cerebrovascular disease, and aging. |
Enabling scientific discoveries that improve human health