| Title: | Central Lean Mass Distribution and the Risks of All-Cause and Cause-Specific Mortality in 40,283 UK Biobank Participants |
| Journal: | Obesity Facts |
| Published: | 24 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39047689/ |
| DOI: | https://doi.org/10.1159/000540219 |
Publication 12783
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Abstract
INTRODUCTION: The purpose of this study was to investigate the association of central lean mass distribution with the risk of mortality.</p>
METHODS: This cohort study included 40,283 UK Biobank participants. Cox proportional hazards regression models were used to estimate the association of central lean mass distribution, i.e., trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, with the risk of mortality.</p>
RESULTS: The median age of the participants was 65 years, and 52% were women. During a median follow-up of 4.18 years, 674 participants died, of whom 366 were due to cancer and 126 were due to cardiovascular causes. Compared with the lowest tertile of a trunk-to-leg lean mass ratio, the multivariable-adjusted (age, sex, ethnicity, lifestyle, comorbidities, body mass index, and appendicular muscle mass index) hazards ratios of the highest tertile of trunk-to-leg lean mass ratio were 1.55 (95% CI: 1.23-1.94), 1.69 (95% CI: 1.26-2.26), and 1.14 (95% CI: 0.72-1.80) for all-cause, cancer, and cardiovascular mortality, respectively. Neutrophil-to-lymphocyte ratio mediated 9.3% (95% CI: 3.3%-40.4%) of the association of trunk-to-leg lean mass ratio with all-cause mortality. There was evidence for additive interactions of trunk-to-leg lean mass ratio with older age and poor diet quality for all-cause mortality.</p>
CONCLUSION: Trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, was positively associated with the risks of all-cause and cancer mortality, independent of general obesity and central obesity, in UK middle-aged and older adults. Central lean mass distribution may interact synergistically with aging and poor diet quality to further increase the risk of death.</p>
17 Keywords
- Absorptiometry, Photon
- Aged
- Biological Specimen Banks
- Body Composition
- Body Mass Index
- Cardiovascular Diseases
- Cause of Death
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
- Proportional Hazards Models
- Risk Factors
- UK Biobank
- United Kingdom
8 Authors
- Li Ding
- Yuxin Fan
- Jiaxing Wang
- Xiaohui Ma
- Lina Chang
- Qing He
- Gang Hu
- Ming Liu
1 Application
| Application ID | Title |
|---|---|
| 68655 | Distribution of fat-free mass and risk of mortality in general adult population and adults with comorbidities |
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