| Title: | Life's Essential 8, Genetic Susceptibility, and Incident Cardiac Arrhythmias: A Population-Based Prospective Cohort Study |
| Journal: | Canadian Journal of Cardiology |
| Published: | 14 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39009185/ |
| DOI: | https://doi.org/10.1016/j.cjca.2024.07.007 |
Publication 12838
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Ideal cardiovascular health (CVH) has been associated with reduced cardiovascular disease risk and mortality, but its association with cardiac arrhythmias was still unsettled. In this prospective cohort study, we investigated the relationship between CVH and subsequent arrhythmias risk, including atrial fibrillation (AF)/flutter, ventricular arrhythmias, and bradyarrhythmias.</p>
METHODS: Data from 287,264 participants initially free of arrhythmias in the UK Biobank were included in the analysis. Cox regression models were used to examine the relationship between CVH levels calculated by the American Heart Association's Life's Essential 8 (LE8) metrics, with cardiac arrhythmias risk.</p>
RESULTS: During a median follow-up period of 12.8 years, 16,802 incident AF, 2186 incident ventricular arrhythmias, and 4128 incident bradyarrhythmias were identified. After adjustment for confounding factors, participants with high initial CVH levels had significantly lower risks for AF (hazard ratio [HR], 0.63; 95% confidence interval [CI], 0.59-0.68), ventricular arrhythmias (HR, 0.48; 95% CI, 0.40-0.59), and bradyarrhythmias (HR, 0.64; 95% CI, 0.55-0.74) compared with those with low CVH levels. Furthermore, each standard deviation (SD) increase in LE8 scores was associated with a 15% lower risk of AF, 21% for ventricular arrhythmias, and 13% for bradyarrhythmias, respectively. In addition, a significant interaction was observed between CVH levels and the genetic risk of AF (P for interaction, 0.021). The reverse correlation seemed to be more noticeable in individuals with a lower genetic susceptibility to AF.</p>
CONCLUSIONS: We concluded that higher levels of CVH, estimated by the LE8 metrics, were associated with significantly reduced risks of AF, ventricular arrhythmias, and bradyarrhythmias.</p>
15 Keywords
- Adult
- Aged
- Arrhythmias, Cardiac
- Atrial Fibrillation
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Health Status
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
10 Authors
- Da-Chuan Guo
- Zhi-Teng Chen
- Xiang Wang
- Jing-Wei Gao
- Qing-Yuan Gao
- Ze-Gui Huang
- Yang-Xin Chen
- Pin-Ming Liu
- Jing-Feng Wang
- Hai-Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 91090 | Predictors of coronary artery calcification (CAC) progression in the UKB population |
Enabling scientific discoveries that improve human health