| Title: | Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity |
| Journal: | Comprehensive Psychoneuroendocrinology |
| Published: | 31 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39211730/ |
| DOI: | https://doi.org/10.1016/j.cpnec.2024.100255 |
Publication 12855
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Abstract
Genetic variations in single nucleotide polymorphisms (SNPs) within oxytocin pathway genes have been linked to social behavior and neurodevelopmental conditions. However, the neurobiological mechanisms underlying these associations remain elusive. In this study, we investigated the relationship between variations of 10 SNPs in oxytocin pathway genes and resting-state functional connectivity among 55 independent components using a large sample from the UK Biobank (N ≈ 30,000). Our findings revealed that individuals with the GG genotype at rs4813627 within the oxytocin structural gene (OXT) exhibited weaker resting-state functional connectivity in the corticostriatal circuit compared to those with the GA/AA genotypes. Empirical evidence has linked the GG genotype at OXT rs4813627 with a behavioral tendency of insensitivity to others. These results inform the neural mechanisms by which oxytocin-related genetic factors can influence social behavior.</p>
7 Authors
- Shanshan Xiao
- Håkan Fischer
- Natalie C. Ebner
- Gull Rukh
- Junhua Dang
- Lars Westberg
- Helgi B. Schiöth
1 Application
| Application ID | Title |
|---|---|
| 30172 | Comorbidities between addiction and mental disorders ? association of genetics, biomarkers and environment (e.g. lifestyle) with mental health and cognitive function |
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