| Title: | Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations |
| Journal: | Heliyon |
| Published: | 9 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39247266/ |
| DOI: | https://doi.org/10.1016/j.heliyon.2024.e36023 |
Publication 12935
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Abstract
Whether all obesity-related variants contribute to the onset of obesity or one or a few variants cause obesity in genetically heterogeneous populations remains obscure. Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants. In Step-2, we assigned participants with obesity (BMI ≥25 kg/m2) to five clusters based on obesity-related factors. Subsequently, participants from each cluster and those with a BMI <25 kg/m2 were combined. A GWAS was conducted for each cluster. Several previously identified obesity-related genes were verified in Step-1. Of the genes detected in Step-1, unique obesity-related genes were detected separately for each cluster in Step-2. Our novel findings suggest that a smaller sample size with increased homogeneity may provide insights into the genetic architecture of obesity.</p>
13 Authors
- Ippei Takahashi
- Hisashi Ohseto
- Fumihiko Ueno
- Tomomi Oonuma
- Akira Narita
- Taku Obara
- Mami Ishikuro
- Keiko Murakami
- Aoi Noda
- Atsushi Hozawa
- Junichi Sugawara
- Gen Tamiya
- Shinichi Kuriyama
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