| Title: | Association of coffee consumption with cardiometabolic multimorbidity: A prospective cohort study in the UK biobank |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 8 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39277537/ |
| DOI: | https://doi.org/10.1016/j.numecd.2024.08.004 |
Publication 12937
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Abstract
BACKGROUND AND AIMS: Previous observational studies have investigated the association between coffee consumption and single cardiometabolic disease. Yet, the extent to which coffee might confer health advantages to individuals with a singular cardiometabolic disease remains unclear. This study aimed to further investigate the association of coffee consumption and the onset and progression from single cardiometabolic disease to cardiometabolic multimorbidity (CMM).</p>
METHODS AND RESULTS: This prospective cohort study included 185,112 participants from the UK Biobank who were enrolled between 2006 and 2010 and followed up until 2020. Coffee consumption was collected using a 24-h dietary questionnaire. CMM was defined as the coexistence of at least two cardiometabolic diseases, including type 2 diabetes (T2D), coronary heart disease (CHD) and stroke. Cox proportional hazards and multi-state models estimated the associations between coffee consumption and CMM. During a median follow-up of 11.4 years, 1585 participants developed CMM. Compared with nonconsumers, coffee consumers had lower risks for the transitions from baseline to single cardiometabolic disease, with the respective lowest hazard ratios and 95% confidence intervals (CIs) for the transitions from baseline to T2D, CHD and stroke after multivariable adjustment being 0.79 (CI, 0.72-0.87), 0.91 (CI, 0.86-0.97) and 0.87 (CI, 0.78-0.96). Coffee consumption resulted in a significant reduction in the risk of the transitions from CHD and stroke to CMM, with the lowest estimates were 0.56 (CI, 0.43-0.73) and 0.60 (CI, 0.43-0.83). Similar associations were observed in unsweetened coffee. Sugar-sweetened coffee was associated with some transitions at low levels of consumption. The associations between artificially sweetened coffee and CMM were less consistent.</p>
CONCLUSIONS: Coffee consumption was associated with lower risk for almost all transition phases of CMM development and consistent findings were observed with unsweetened coffee.</p>
21 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cardiometabolic Risk Factors
- Coffee
- Coronary Disease
- Diabetes Mellitus, Type 2
- Disease Progression
- Female
- Humans
- Male
- Middle Aged
- Multimorbidity
- Prognosis
- Prospective Studies
- Protective Factors
- Risk Assessment
- Stroke
- Time Factors
- UK Biobank
- United Kingdom
7 Authors
- Dingkui Sun
- Yinyan Gao
- Boya Xu
- Linghui Xiang
- Wenqi Liu
- Han Luo
- Irene X Y Wu
1 Application
| Application ID | Title |
|---|---|
| 64555 | Interaction effect of physical activity and environmental factors on health outcomes in general populations |
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