| Title: | The Association Between Plasma Fatty Acids and Risk of Lung Cancer: A Prospective Cohort Study of the UK Biobank |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 3 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39225141/ |
| DOI: | https://doi.org/10.1210/clinem/dgae609 |
Publication 13032
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Fatty acids (FAs) have emerged as significant contributors to tumorigenesis, yet prospective evidence regarding their specific effects on lung cancer risk remains scarce.</p>
OBJECTIVE: To investigate the association between plasma FAs and lung cancer incidence, as well as a potential modification effect of genetic susceptibility on lung cancer risk.</p>
METHODS: A cohort study was conducted involving 112 547 cancer-free participants from the UK Biobank, with measurements of plasma FAs, including saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs), at baseline (2006-2010). Cox regression models were employed to assess lung cancer risk according to plasma FA quartiles or 1-SD increments. Furthermore, interaction between plasma FAs and polygenic risk score was evaluated using an additive model.</p>
RESULTS: Over an average 10.9-year follow-up, 1122 lung cancer cases occurred. After multivariable adjustment, MUFAs were positively associated with lung cancer risk (hazard ratio [HR] per 1-SD = 1.32; 95% CI, 1.13-1.54). In contrast, PUFAs, particularly n-3 PUFAs, n-6 PUFAs, docosahexaenoic acid, and linoleic acid, were associated with a lower risk of lung cancer, with HRs ranging from 0.79 (95% CI, 0.72-0.87) to 0.89 (95% CI, 0.83-0.95). SFAs were not significantly associated with lung cancer risk. Moreover, we observed an additive interaction between plasma PUFAs and genetic risk. Individuals with a high genetic risk and the lowest quartile of plasma PUFAs had the highest risk of lung cancer (HR = 2.20, 95% CI, 1.43-3.38).</p>
CONCLUSION: Our findings suggest that plasma PUFAs may serve as protective factors, while MUFAs represent risk factors for lung cancer, offering novel insights into lung cancer carcinogenesis and prevention.</p>
17 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Fatty Acids
- Fatty Acids, Unsaturated
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Incidence
- Lung Neoplasms
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- UK Biobank
- United Kingdom
10 Authors
- Jianv Huang
- Jiacong Li
- Lu He
- Junyan Miao
- Meng Zhu
- Juncheng Dai
- Guangfu Jin
- Hongxia Ma
- Dong Hang
- Hongbing Shen
Enabling scientific discoveries that improve human health