| Title: | Rare Genetic Variants in LDLR, APOB, and PCSK9 Are Associated With Aortic Stenosis |
| Journal: | Circulation |
| Published: | 2 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39222019/ |
| DOI: | https://doi.org/10.1161/circulationaha.124.070982 |
Publication 13136
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Abstract
BACKGROUND: Despite a proposed causal role for LDL-C (low-density lipoprotein cholesterol) in aortic stenosis (AS), randomized controlled trials of lipid-lowering therapy failed to prevent severe AS. We aimed to assess the impact on AS and peak velocity across the aortic valve conferred by lifelong alterations in LDL-C levels mediated by protein-disrupting variants in 3 clinically significant genes for LDL (low-density lipoprotein) metabolism (LDLR, APOB, and PCSK9).</p>
METHODS: We used sequencing data and electronic health records from UK Biobank (UKB) and All of Us and magnetic resonance imaging data from UKB. We identified predicted protein-disrupting variants with the Loss Of Function Transcript Effect Estimator (LOFTEE) and AlphaMissense algorithms and evaluated their associations with LDL-C and peak velocity across the aortic valve (UK Biobank), as well as diagnosed AS and aortic valve replacement (UK Biobank and All of Us).</p>
RESULTS: We included 421 049 unrelated participants (5621 with AS) in UKB and 195 519 unrelated participants (1087 with AS) in All of Us. Carriers of protein-disrupting variants in LDLR had higher mean LDL-C (UKB: +42.6 mg/dL; P=4.4e-237) and greater risk of AS (meta-analysis: odds ratio, 3.52 [95% CI, 2.39-5.20]; P=2.3e-10) and aortic valve replacement (meta-analysis: odds ratio, 3.78 [95% CI, 2.26-6.32]; P=4.0e-7). Carriers of protein-disrupting variants in APOB or PCSK9 had lower mean LDL-C (UKB: -32.3 mg/dL; P<5e-324) and lower risk of AS (meta-analysis: odds ratio, 0.49 [95% CI, 0.31-0.75]; P=0.001) and aortic valve replacement (meta-analysis: odds ratio, 0.54 [95% CI, 0.30-0.97]; P=0.04). Among 57 371 UKB imaging substudy participants, peak velocities across the aortic valve were greater in carriers of protein-disrupting variants in LDLR (+12.2 cm/s; P=1.6e-5) and lower in carriers of protein-disrupting variants in PCSK9 (-6.9 cm/s; P=0.022).</p>
CONCLUSIONS: Rare genetic variants that confer lifelong higher or lower LDL-C levels are associated with substantially increased and decreased risk of AS, respectively. Early and sustained lipid-lowering therapy may slow or prevent AS development.</p>
13 Keywords
- Aged
- Aortic Valve
- Aortic Valve Stenosis
- Apolipoprotein B-100
- Cholesterol, LDL
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Male
- Middle Aged
- Proprotein Convertase 9
- Receptors, LDL
11 Authors
- Joel T. Rämö
- Sean J. Jurgens
- Shinwan Kany
- Seung Hoan Choi
- Xin Wang
- Andrey N. Smirnov
- Samuel F. Friedman
- Mahnaz Maddah
- Shaan Khurshid
- Patrick T. Ellinor
- James P. Pirruccello
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