| Title: | Increased Risk of Chronic Respiratory Disease among Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study |
| Journal: | The American Journal of Medicine |
| Published: | 5 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39370033/ |
| DOI: | https://doi.org/10.1016/j.amjmed.2024.09.001 |
Publication 13279
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Abstract
BACKGROUND: Cross-sectional evidence suggests a higher burden of chronic respiratory diseases in people with inflammatory bowel disease, but there is a lack of prospective evidence to clarify the direction of their associations. We aimed to investigate the association of inflammatory bowel disease with the risk of 2 major chronic respiratory diseases, chronic obstructive pulmonary disease, and asthma.</p>
METHODS: We included 430,414 participants from UK Biobank and followed them from recruitment (2006-2010) to 2021. Chronic obstructive pulmonary disease and asthma cases were obtained from inpatient data and death register. Using Cox proportional hazards models, we estimated the multivariable-adjusted hazard ratios (HR) of developing chronic obstructive pulmonary disease and asthma in participants with inflammatory bowel disease compared with inflammatory bowel disease-free groups. We also investigated the association among Crohn's disease and ulcerative colitis with the risk of chronic obstructive pulmonary disease and asthma.</p>
RESULTS: Over a median follow-up of 11.9 years, there were 11,196 incidents of chronic obstructive pulmonary disease and 9831 asthma cases. The adjusted HRs of developing chronic obstructive pulmonary disease (HR 1.54; 95% confidence interval [CI], 1.33-1.79) and asthma (HR 1.52; 95% CI, 1.29-1.79) were higher for those with inflammatory bowel disease when compared with inflammatory bowel disease-free participants. Participants with Crohn's disease and ulcerative colitis were also found to have a higher risk of chronic obstructive pulmonary disease (Crohn's disease: HR 1.71; 95% CI, 1.36-2.15; ulcerative colitis: HR 1.45; 95% CI, 1.20-1.75) and asthma (Crohn's disease: HR 1.73; 95% CI, 1.33-2.25; ulcerative colitis: HR 1.41; 95% CI, 1.15-1.73) when compared with those free of inflammatory bowel disease.</p>
CONCLUSIONS: This study suggested that individuals with inflammatory bowel disease have a higher risk of developing chronic obstructive pulmonary disease and asthma, highlighting the importance of preventing chronic respiratory diseases among inflammatory bowel disease patients.</p>
15 Keywords
- Adult
- Aged
- Asthma
- Colitis, Ulcerative
- Crohn Disease
- Female
- Humans
- Inflammatory Bowel Diseases
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
- Risk Factors
- United Kingdom
9 Authors
- Lintao Dan
- Ying Xie
- Tian Fu
- Yuhao Sun
- Xuejie Chen
- Xiaoyan Wang
- Chenkai Wu
- Jie Chen
- Xue Li
2 Applications
| Application ID | Title |
|---|---|
| 66354 | Investigating the genetic, environmental and clinical determinants and their interactions on cancer risk, and developing risk prediction and prognosis models for common cancer types |
| 79612 | Disentangle the interplay between genetic predisposition, social environment, and lifestyle in the development of complex and common aging-related diseases and syndromes |
Enabling scientific discoveries that improve human health