| Title: | Alcohol Intake and Endogenous Hormones in Pre- and Postmenopausal Women: Findings from the UK Biobank |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 4 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34607837/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-21-0789 |
| URL: | https://aacrjournals.org/cebp/article-pdf/30/12/2294/3014909/2294.pdf |
Publication 13805
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Abstract
BACKGROUND: Alcohol intake may influence breast cancer risk in women through hormonal changes, but the evidence to date is inconclusive. We investigated cross-sectional associations between habitual alcohol intake and serum concentrations of testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and estradiol (premenopausal women only) in UK Biobank.</p>
METHODS: We included 30,557 premenopausal and 134,029 postmenopausal women aged between 40 and 69 years when recruited between 2006 and 2010. At their initial assessment visit, habitual alcohol intake was assessed using a touchscreen questionnaire, and serum hormone concentrations were assayed. Multivariable linear regression analysis was performed.</p>
RESULTS: Per 10 g/day increment in alcohol intake, testosterone concentration was 3.9% [95% confidence intervals (CI): 3.3%-4.5%] higher in premenopausal women and 2.3% (1.8%-2.7%) higher in postmenopausal women (P heterogeneity < 0.0001); SHBG concentration was 0.7% (0.2%-1.1%) higher in premenopausal women and 2.4% (2.2%-2.6%) lower in postmenopausal women (P heterogeneity < 0.0001); and IGF-1 concentration was 1.9% (1.7%-2.1%) lower in premenopausal women and 0.8% (0.6%-0.9%) lower in postmenopausal women (P heterogeneity < 0.0001). In premenopausal women, there was no significant overall association of alcohol with estradiol but a positive association was observed in the early and mid-luteal phases: 1.9% (95% CI: 0.2%-3.6%) and 2.4% (95% CI: 0.7%-4.2%) higher, respectively.</p>
CONCLUSIONS: This study confirms significant but modest associations between alcohol intake and hormones, with evidence of heterogeneity by menopausal status.</p>
IMPACT: The findings facilitate better understanding of whether alcohol intake influences hormone concentrations, but further work is necessary to fully understand the mechanisms linking alcohol with cancer risk.</p>
15 Keywords
- Adult
- Aged
- Alcohol Drinking
- Breast Neoplasms
- Female
- Gonadal Steroid Hormones
- Humans
- Insulin-Like Growth Factor I
- Middle Aged
- Postmenopause
- Premenopause
- Prospective Studies
- Risk Assessment
- Sex Hormone-Binding Globulin
- United Kingdom
3 Authors
- Sandar Tin Tin
- Timothy J. Key
- Gillian K. Reeves
1 Application
| Application ID | Title |
|---|---|
| 3248 | Hormones and Breast Cancer Consortium: Risk factors for breast cancer |
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