| Title: | Maternal smoking during pregnancy is risk factor for gallbladder disease in offspring during adulthood: a prospective study from UK Biobank |
| Journal: | Annals of Hepatology |
| Published: | 13 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34653688/ |
| DOI: | https://doi.org/10.1016/j.aohep.2021.100558 |
Publication 13807
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
INTRODUCTION AND OBJECTIVES: Gallbladder disease is a common disease with high prevalence. Majority of gallbladder disease is due to gallstone. Though genetics are believed to play a role in its pathogenesis, the contribution of environmental pressures in early life to the development of this disease in adulthood has not been ever investigated. This study aimed to clarify the risk of maternal smoking exposure in association with gallbladder disease in adulthood. The interaction of maternal smoking and own smoking during adulthood on this association was studied as well.</p>
PATIENTS AND METHODS: A total of 286,731 eligible participants from the UK Biobank population-based cohort were included. Multivariable Cox regression analysis were used to examine the HR and 95% CI with adjustment for covariates.</p>
RESULT: During a median of 8.8 years follow-up, 7110 incident cases of gallbladder disease including 6800 (95.6%) gallstone were identified. Maternal smoking was associated with increased risk of incident total gallbladder disease (HR = 1.13; 95%CI: 1.06 - 1.21; P = 0.0002) as well as gallstones (HR = 1.13; 95%CI: 1.06 -1.21; P = 0.0003) in adulthood. Compared with those who were neither exposed to maternal smoking nor own smoking, subjects adherence to no smoking during adulthood but having maternal smoking exposure still had increased risk of total gallbladder disease (HR = 1.21; 95%CI: 1.1-1.34, P=0.0001) and gallstones (HR = 1.21; 95%CI: 1.1-1.35, P=0.0001).</p>
CONCLUSION: The present study using large prospective cohort data from UK Biobank, for the first time, demonstrated maternal smoking exposure bringing elevated risk of incident total gallbladder disease/gallstone in adulthood.</p>
16 Keywords
- Biological Specimen Banks
- Female
- Follow-Up Studies
- Gallbladder Diseases
- Humans
- Male
- Middle Aged
- Morbidity
- Pregnancy
- Prenatal Exposure Delayed Effects
- Prospective Studies
- Risk Assessment
- Risk Factors
- Smoking
- Time Factors
- United Kingdom
7 Authors
- Wenxiang Li
- Jingjia Liang
- Wentao Shao
- Cheng Xu
- Jin Xu
- Zhaoyan Jiang
- Aihua Gu
Enabling scientific discoveries that improve human health