| Title: | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| Journal: | Ecotoxicology and Environmental Safety |
| Published: | 23 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39719816/ |
| DOI: | https://doi.org/10.1016/j.ecoenv.2024.117582 |
Publication 13954
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Abstract
BACKGROUND: The association between co-exposure to multiple air pollutants and the occurrence of chronic kidney disease (CKD) was not well-established, and the mediating role of accelerated aging in this association remained uncertain.</p>
METHODS: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM2.5, PM10, PM2.5-10, NO2 and NOx, and the incidence of CKD by calculating an air pollution score. Mediation analyses were performed to examine the mediating role of accelerated aging (PhenoAgeAccel or KDM-BioAgeAccel) in this association.</p>
RESULTS: During the median follow-up time of 12.9 years, 11,117 participants developed CKD. The results showed that per interquartile range (IQR) increment in air pollution score led to an approximately 9.0 % (6.6-11.4 %) elevated risk of occurring CKD. Compared to the first quartile (Q1) of air pollution score, those in the highest quartile (Q4) had a 21.2 % (14.8-27.9 %) higher risk of developing CKD (Ptrend<0.001). Mediation analyses suggested that PhenoAgeAccel and KDM-BioAgeAccel significantly mediated 1.5 % and 5.7 % of the association between air pollution score and incident CKD, respectively.</p>
CONCLUSION: Co-exposure to multiple air pollutants could increase the risk of developing CKD, with accelerated aging serving as a partial mechanism in the relationship between air pollution and CKD. These findings highlight the importance of reducing air pollution, and suggest a possible mechanism from air pollution to CKD through accelerated aging.</p>
16 Keywords
- Adult
- Aged
- Aging
- Air Pollutants
- Air Pollution
- Cohort Studies
- Environmental Exposure
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Particulate Matter
- Renal Insufficiency, Chronic
- Risk Factors
- United Kingdom
9 Authors
- Shuo Zhang
- Yuxin Liu
- Jike Qi
- Yu Yan
- Tongyu Gao
- Xin Zhang
- Dong Sun
- Ting Wang
- Ping Zeng
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
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