| Title: | The role of C-reactive protein and genetic predisposition in the risk of psoriasis: results from a national prospective cohort |
| Journal: | BMC Rheumatology |
| Published: | 21 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39707502/ |
| DOI: | https://doi.org/10.1186/s41927-024-00450-2 |
Publication 13958
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Abstract
BackgroundPsoriasis is an immune-mediated chronic inflammatory disease associated with multiple factors. To evaluate the extent to which C-reactive protein (CRP) and genetic predisposition affect the incidence of psoriasis.MethodsThe cohort study retrieved 420,040 participants without psoriasis at baseline from the UK Biobank. Serum CRP was categorized into two levels: < 2 mg/L (normal) and ≥ 2 mg/L (elevated). The polygenic risk score (PRS) was used to estimate genetic predisposition, and was characterized as low, moderate and high PRS. The possible interaction and joint associations between CRP and PRS were assessed using Cox proportional hazards models.ResultsParticipants with high CRP levels had an increased risk of incident psoriasis compared to those with low CRP levels (HR: 1.26, 95% CI: 1.18-1.34). Participants with high CRP levels and high PRS had the highest risk of incident psoriasis [2.24 (95% CI: 2.01, 2.49)], compared with those had low CRP levels and low PRS. Significant additive and multiplicative interaction were found between CRP and PRS in relation to the incidence of psoriasis.ConclusionsOur results suggest that higher CRP concentration may be associated with higher psoriasis incidence, with a more pronounced association observed in individuals with high PRS for psoriasis. So, clinicians should be aware that the risk of incident psoriasis may increase in general population with high CRP levels and high PRS, so that early investigation and intervention can be initiated.</p>
8 Authors
- Huarun Li
- Haobin Zhang
- Xiangyue Zhao
- Jinping Huang
- Junguo Zhang
- Zhaoyan Liu
- Ju Wen
- Si Qin
1 Application
| Application ID | Title |
|---|---|
| 69550 | Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances |
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