| Title: | Associations between endogenous sex hormones and multisite chronic musculoskeletal pain |
| Journal: | British Journal of Anaesthesia |
| Published: | 19 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39706703/ |
| DOI: | https://doi.org/10.1016/j.bja.2024.11.021 |
Publication 13965
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Abstract
BACKGROUND: Sex-differences in pain perception have been documented; however, the role of sex hormones in chronic musculoskeletal pain (CMP) remains unclear. Therefore, this study investigated whether sex hormones and sex hormone-binding globulin (SHBG) are associated with CMP.</p>
METHODS: We utilised data from the UK Biobank (n=357 424; females: 51.6%; white: 95.2%). Serum concentrations of oestradiol (E2), testosterone (T), and SHBG were measured at baseline. Chronic pain (≥3 months) in the neck/shoulder, back, hip, knee, or 'all over the body' was assessed at baseline and three follow-ups. Mixed-effects multinomial/logistic regression models were used.</p>
RESULTS: In multivariable analyses, greater concentrations of T and T/SHBG were associated with a lower number of CMP sites in both males (T: relative risk ratio=0.81 per standard deviation, 95% confidence interval [0.77-0.86] and T/SHBG: 0.85 [0.80-0.92]) and females (T: 0.85 [0.81-0.89] and T/SHBG: 0.93 [0.89-0.97] [all P-values for trend ≤0.001]). Greater T concentrations and T/SHBG were also associated with lower odds of CMP across all sites, while higher concentrations of SHBG were associated with lower odds of neck/shoulder CMP in both sexes. There was no association between concentrations of E2, SHBG, or E2/SHBG and number of CMP or site-specific CMP in either sex.</p>
CONCLUSION: In both sexes, greater T concentrations and T/SHBG were associated with lower number of CMP sites and site-specific CMP, while greater concentrations of SHBG were linked to lower odds of neck/shoulder CMP. These findings suggest a potential involvement of sex steroids in the pathogenesis of CMP and underscore the need for further investigation into their potential in chronic pain management strategies.</p>
7 Authors
- Zemene Demelash Kifle
- Jing Tian
- Dawn Aitken
- Phillip E Melton
- Flavia Cicuttini
- Graeme Jones
- Feng Pan
1 Application
| Application ID | Title |
|---|---|
| 68213 | Impact of multisite musculoskeletal pain and its mechanism |
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