| Title: | The Association of Dietary Polyamines with Mortality and the Risk of Cardiovascular Disease: A Prospective Study in UK Biobank |
| Journal: | Nutrients |
| Published: | 16 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39770955/ |
| DOI: | https://doi.org/10.3390/nu16244335 |
Publication 13982
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Abstract
BACKGROUND: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD).</p>
METHODS: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire. Diet was assessed using Oxford WebQ, a web-based 24 h recall questionnaire, with polyamines intakes estimated from previous studies. Cox proportional models with restricted cubic splines were employed to investigate nonlinear associations. The primary endpoint was all-cause mortality or incident CVD (including CVD death, coronary heart disease and stroke).</p>
RESULTS: During a median follow-up period of 11.5 years, 7348 (3.9%) participants died and 12,316 (6.5%) developed incident CVD. Polyamines intake showed nonlinear associations with all-cause mortality and incident CVD (P for nonlinear < 0.01). Compared to the lowest quintile group of dietary polyamines intake (≤17.4 mg/day), the quintile 2 to 5 groups demonstrated a reduced risk of all-cause mortality, with the lowest risk in quintile 2 group (>17.4-22.3 mg/day) (HR:0.82, 95% CI: 0.76-0.88). Similar results were observed for incident CVD, with the lowest risk in the quintile 4 group (>27.1-33.5 mg/day) (HR: 0.86, 95% CI: 0.82-0.92).</p>
CONCLUSIONS: We found that dietary polyamines intake was associated with a lower risk of all-cause mortality or incident CVD. Furthermore, our study identified an optimal range of dietary polyamines intake.</p>
19 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cardiovascular Diseases
- Diet
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Polyamines
- Proportional Hazards Models
- Prospective Studies
- Putrescine
- Risk Factors
- Spermidine
- Spermine
- UK Biobank
- United Kingdom
9 Authors
- Su Han
- Mingxia Qian
- Na Zhang
- Rui Zhang
- Min Liu
- Jiangbo Wang
- Furong Li
- Liqiang Zheng
- Zhaoqing Sun
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