| Title: | The various associations between whole /regional fat mass and trajectory of cardiometabolic diseases: a nonlinear multistate model |
| Journal: | Obesity |
| Published: | 16 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39682065/ |
| DOI: | https://doi.org/10.1002/oby.24185 |
Publication 13983
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Abstract
OBJECTIVE: This study aimed to investigate the association of whole body/regional fat mass (FM) with cardiometabolic disease (CMD) trajectory.</p>
METHODS: We conducted a prospective analysis using the UK Biobank. The FM index (FMI), a surrogate for whole body FM, and regional FM (i.e., arm, leg, and trunk) were examined as exposures. A nonlinear multistate framework was used to evaluate the association between whole/regional FM and CMD trajectory.</p>
RESULTS: Among the 423,966 participants (mean age 56.1 [SD 8.10] years, 43.9% men) with a median follow-up of 13.5 years, varied associations were identified between whole/regional FM and transitions in the CMD trajectory. Upper body FM (i.e., arm and trunk) exhibited significant positive J-shaped associations in the transitions from first CMD (FCMD) or cardiometabolic multimorbidity to death; however, FMI and leg FM demonstrated L-shaped associations. Leg FM played a beneficial role in the transition from FCMD to death, with a hazard ratio of 0.950 (95% CI: 0.931-0.968) per 1 kg.</p>
CONCLUSIONS: Body fat composition and distribution revealed various associations with CMD trajectory, highlighting their clinical importance. Upper body FM among those participants with FCMD or cardiometabolic multimorbidity demonstrated positive J-shaped associations toward death, providing no evidence of the "obesity paradox."</p>
14 Keywords
- Adipose Tissue
- Adiposity
- Adult
- Aged
- Body Composition
- Cardiometabolic Risk Factors
- Cardiovascular Diseases
- Female
- Humans
- Male
- Middle Aged
- Obesity
- Prospective Studies
- United Kingdom
11 Authors
- Xinming Xu
- Yi Guo
- Lili Huang
- Berty Ruping Song
- Dan Chen
- Fangfang Weng
- Xueying Zheng
- Yu Wen
- Zhenyu Wu
- Xiang Gao
- Liang Sun
1 Application
| Application ID | Title |
|---|---|
| 96083 | Associations of diet and metabolic profile with risk of cardiometabolic disease and neurodegenerative disease |
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