| Title: | Dietary N-6 Polyunsaturated Fatty Acid Intake and Brain Health in Middle-Aged and Elderly Adults |
| Journal: | Nutrients |
| Published: | 11 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39770894/ |
| DOI: | https://doi.org/10.3390/nu16244272 |
Publication 14004
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Abstract
BACKGROUND: Dietary intake of polyunsaturated fatty acids (PUFA) plays a significant role in the onset and progression of neurodegenerative diseases. Since the neuroprotective effects of n-3 PUFA have been widely validated, the role of n-6 PUFA remains debated, with their underlying mechanisms still not fully understood.</p>
METHODS: In this study, 169,295 participants from the UK Biobank were included to analyze the associations between dietary n-6 PUFA intake and neurodegenerative diseases using Cox regression models with full adjustments for potential confounders. In addition, multiple linear regression models were utilized to estimate the impact of n-6 PUFA intake on brain imaging phenotypes.</p>
RESULTS: Results indicated that low dietary n-6 PUFA intake was associated with increased risks of incident dementia (hazard ratio [95% confidence interval] = 1.30 [1.13, 1.49]), Parkinson's disease (1.42 [1.16, 1.74]), and multiple sclerosis (1.65 [1.03, 2.65]). Moreover, the low intake was linked to diminished volumes of various brain structures, including the hippocampus (β [95% confidence interval] = -0.061 [-0.098, -0.025]), thalamus (-0.071 [-0.105, -0.037]), and others. White matter integrity was also found to be compromised in individuals with low n-6 PUFA intake.</p>
CONCLUSIONS: These findings enhanced our understanding of how dietary n-6 PUFA intake might affect neurological health, thereby providing epidemiological evidence for future clinical and public health interventions.</p>
16 Keywords
- Aged
- Brain
- Dementia
- Diet
- Fatty Acids, Omega-6
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Multiple Sclerosis
- Neurodegenerative Diseases
- Parkinson Disease
- Proportional Hazards Models
- Risk Factors
- United Kingdom
8 Authors
- Jiawei Gu
- Yujia Bao
- Yongxuan Li
- Li Hua
- Xiaobei Deng
- Yuzheng Zhang
- Xiaojun Zhu
- Jinjun Ran
Enabling scientific discoveries that improve human health