| Title: | Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases |
| Journal: | Annals of Hepatology |
| Published: | 4 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39638041/ |
| DOI: | https://doi.org/10.1016/j.aohep.2024.101750 |
Publication 14056
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Abstract
INTRODUCTION AND OBJECTIVES: Recently, Delphi consensus proposed an overarching term steatotic liver disease (SLD), with various subcategories such as MASLD, MetALD and ALD. Our aim was to investigate the association between MASLD/MetALD/ALD and four intrahepatic and extrahepatic diseases (liver diseases, renal diseases, cardiovascular diseases, and cancers) in the UK Biobank cohort.</p>
PATIENTS AND METHODS: By defining hepatic steatosis as image-derived phenotype (IDP)-PDFF >5.21%, we used data from the UK Biobank to diagnose MASLD/ MetALD/ALD. The odd ratio (OR) and the hazard ratio (HR) were calculated using the logistic regression modals and Cox regression models, respectively.</p>
RESULTS: Among 39,230 eligible individuals, 6,865 MASLD subjects, 2,379 MetALD subjects and 884 ALD subjects were diagnosed. The last follow-up time was October 13, 2023. Consistent with the logistic analyses, MASLD/MetALD/ALD were significantly associated with a higher risk of liver diseases (HR=3.04 [95%CI:2.60-3.56], HR = 2.69 [95% CI: 2.12-3.42] and HR =3.99 [95%CI:2.92-5.45], respectively). Subjects with MASLD also had an increased higher risk of renal diseases (HR = 1.40 [95%CI:1.20-1.64]) and subjects with ALD had an increased higher risk of cancers (HR = 1.36 [95%CI:1.15-1.60]).</p>
CONCLUSION: It is the first study to report the association between MASLD, MetALD, ALD and common intrahepatic and extrahepatic diseases based on magnetic resonance imaging data-PDFF. We found that MASLD, MetALD and ALD were risk factors for liver diseases. Meanwhile, MASLD was also a risk factor for renal diseases and ALD was a risk factor for cancers.</p>
9 Authors
- Yiyuan Xiao
- Sihua Xu
- Wenyan Hu
- Jiapeng Huang
- Deke Jiang
- Rong Na
- Zhaoqing Yin
- Jingjing Zhang
- Haitao Chen
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