| Title: | Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 7 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39521435/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2024.11.001 |
Publication 14194
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Abstract
BACKGROUND: Choline, an essential nutrient, plays a critical role in cognition, and may help prevent dementia and mild cognitive impairment. However, studies on dietary choline and its derivatives for preventing these conditions are limited and inconsistent.</p>
OBJECTIVE: The objective of this study was to explore the associations between dietary choline intake and the incidence of dementia, Alzheimer disease (AD), mild cognitive impairment (MCI), and current cognitive performance in the United Kingdom Biobank cohort.</p>
METHODS: Dietary choline intake was categorized into quartiles of consumption based on 24-h dietary recalls, with units expressed as milligrams per day. Diagnoses of dementia, AD, and MCI were identified using the International Classification of Diseases (ICD-9/10) codes. Current cognitive performance was assessed via the computerized touchscreen interface. After adjusting for sociodemographic factors, dietary and lifestyle behaviors, and comorbid conditions, Cox proportional hazards regression, logistic regression, and restricted cubic splines were used to analyze the association between choline intake and dementia or cognitive performance.</p>
RESULTS: Among 125,594 participants (55.8% female), with a mean age of 56.1 y (range: 40-70 years) at baseline and a median follow-up of 11.8 y, 1103 cases of dementia (including 385 AD and 87 cases of MCI) were recorded. U-shaped associations were observed between choline intake and dementia and AD. Participants in the 2nd quartile of total choline intake had lower risks than those in the lowest quartile, with HR of 0.80 (95% CI: 0.67, 0.96) for dementia and 0.76 (95% CI: 0.58, 1.00) for AD. Moderate intake of choline derivative, including free choline (HR, 0.77; 95%CI, 0.65, 0.92), phosphatidylcholine (HR 0.82; 95% CI: 0.68, 0.98), sphingomyelin (HR 0.82; 95% CI: 0.69, 0.98) and glycerophosphocholine (HR 0.83; 95% CI: 0.70, 1.00), were associated with a 17%-23% lower odds of dementia. Additionally, moderate total choline intake was associated with an 8%-13% lower odds of poor cognitive performance in visual attention (OR: 0.92; 95% CI: 0.86, 0.99), fluid intelligence (OR: 0.87; 95% CI: 0.82, 0.92), and complex processing speed (OR: 0.90; 95% CI: 0.84, 0.95).</p>
CONCLUSIONS: In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.</p>
16 Keywords
- Adult
- Aged
- Alzheimer Disease
- Choline
- Cognition
- Cognitive Dysfunction
- Cohort Studies
- Dementia
- Diet
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- United Kingdom
13 Authors
- Ying-Ying Niu
- Hao-Yu Yan
- Jian-Feng Zhong
- Zhi-Quan Diao
- Jing Li
- Cheng-Ping Li
- Lian-Hong Chen
- Wen-Qi Huang
- Miao Xu
- Zhi-Tong Xu
- Xiao-Feng Liang
- Zhi-Hao Li
- Dan Liu
1 Application
| Application ID | Title |
|---|---|
| 83259 | Lifestyle and environmental factors in relation to risks of major chronic diseases and mortality. |
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