| Title: | Chronic Musculoskeletal Pain and Risk of Incident Parkinson's Disease: A 13-Year Longitudinal Study |
| Journal: | Movement Disorders |
| Published: | 2 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39487703/ |
| DOI: | https://doi.org/10.1002/mds.30046 |
Publication 14217
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Abstract
BACKGROUND: Chronic musculoskeletal pain often co-occurs with Parkinson's disease (PD); however, whether individuals with chronic pain have a higher risk of developing PD is unclear.</p>
OBJECTIVES: To investigate the associations between chronic pain and incident risk of three neurodegenerative parkinsonism categories including PD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP).</p>
METHODS: This study included 355,890 participants (mean [standard deviation] age, 56.51 [8.07] years, 48.40% male) who did not have parkinsonism at baseline from a population-based cohort. Musculoskeletal pain in the hip, neck/shoulder, back, knee, or "all over the body" was assessed. Chronic pain was defined if pain lasted ≥3 months. Participants were categorized into four groups: no chronic pain, having one or two, three or four sites, and pain "all over the body." The diagnosis of PD, MSA, and PSP used self-reports, hospital records, and death registries. Multivariable-adjusted Cox regression was performed for the analyses.</p>
RESULTS: Over a median follow-up of 13.0 years, 2044 participants developed PD, 77 participants developed MSA, and 126 participants developed PSP. In multivariable analyses, there was a dose-response relationship between number of chronic pain sites and incident risk of PD (hazard ratio, 1.15; 95% confidence interval, 1.07-1.23). Participants with one or two pain sites and three or four pain sites had an 11% and 49% increased risk of developing PD, respectively. There were no associations between chronic pain and MSA or PSP.</p>
CONCLUSIONS: Chronic musculoskeletal pain was independently associated with PD, suggesting that chronic pain could be used to identify individuals at risk of developing PD. © 2024 International Parkinson and Movement Disorder Society.</p>
8 Authors
- Fatemeh Vazirian
- Jing Tian
- Jane Alty
- Dawn Aitken
- Michele L. Callisaya
- Flavia Cicuttini
- Graeme Jones
- Feng Pan
1 Application
| Application ID | Title |
|---|---|
| 68213 | Impact of multisite musculoskeletal pain and its mechanism |
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