| Title: | Diet quality patterns and chronic kidney disease incidence: a UK Biobank cohort study |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 10 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39667719/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2024.12.005 |
Publication 14229
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Abstract
BACKGROUND: Only a few studies have investigated the role of diet on the risk of chronic kidney disease (CKD) in European populations and have mainly focused on the Mediterranean diet. This is the first study to evaluate the association between various diet quality indices and CKD incidence in British adults.</p>
OBJECTIVE: To study the relationship between a set of 6 different diet quality indices and CKD incidence among British adults.</p>
METHODS: A prospective cohort with 106,870 participants from the UK Biobank, followed from 2009 to 2012 through 2021. Food consumption was obtained from ≥2 24-h dietary assessments. Dietary patterns were assessed using previously established indices: Alternate Mediterranean Index (aMED), Alternative Healthy Eating Index 2010, dietary approaches to stop hypertension (DASH), healthful plant-based diet index (hPDI), unhealthful plant-based diet index (uPDI), and dietary inflammatory index (DII). Incident CKD was obtained from clinical records, death registries, and self-reports. Analyses were performed with Cox regression models and adjusted for the main confounders.</p>
RESULTS: After a median follow-up of 9.27 y, 2934 cases of CKD were ascertained. Hazard ratios (95% confidence interval) of CKD for the highest compared with lowest tertile of adherence to each diet score were 0.84 (0.76, 0.93) for aMED, 0.94 (0.85, 1.03) for alternative healthy eating index 2010, 0.77 (0.70, 0.85) for DASH, 0.79 (0.72, 0.87) for hPDI, 1.27 (1.16, 1.40) for uPDI, and 1.20 (1.18, 1.33) for DII. The results were robust in sensitivity analyses.</p>
CONCLUSIONS: In British adults, higher adherence to the aMED, DASH, and hPDI patterns was associated with lower risk of CKD, whereas greater adherence to the uPDI and DII patterns was associated with greater risk.</p>
17 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cohort Studies
- Diet
- Diet, Healthy
- Diet, Mediterranean
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Renal Insufficiency, Chronic
- Risk Factors
- UK Biobank
- United Kingdom
6 Authors
- Javier Maroto-Rodriguez
- Rosario Ortolá
- Veronica Cabanas-Sanchez
- David Martinez-Gomez
- Fernando Rodriguez-Artalejo
- Mercedes Sotos-Prieto
1 Application
| Application ID | Title |
|---|---|
| 80773 | The effect of novel Healthy Lifestyle Scores in the association of frailty and chronic pain with risk of cancer and CVD, as well as all-cause and cause-specific mortality in British adults |
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