| Title: | Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank |
| Journal: | Communications Medicine |
| Published: | 26 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39592839/ |
| DOI: | https://doi.org/10.1038/s43856-024-00669-7 |
Publication 14257
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Abstract
BackgroundDiagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and presence of comorbid conditions. ME/CFS patients often present with multiple health issues, therefore, incorporating comorbidities into research can provide a more accurate understanding of the condition's symptomatology and severity, to better reflect real-life patient experiences.MethodsWe performed association studies and machine learning on 1194 ME/CFS individuals with blood plasma nuclear magnetic resonance (NMR) metabolomics profiles, and seven exclusive comorbid cohorts: hypertension (n = 13,559), depression (n = 2522), asthma (n = 6406), irritable bowel syndrome (n = 859), hay fever (n = 3025), hypothyroidism (n = 1226), migraine (n = 1551) and a non-diseased control group (n = 53,009).ResultsWe present a lipoprotein perspective on ME/CFS pathophysiology, highlighting gender-specific differences and identifying overlapping associations with comorbid conditions, specifically surface lipids, and ketone bodies from 168 significant individual biomarker associations. Additionally, we searched for, trained, and optimised a machine learning algorithm, resulting in a predictive model using 19 baseline characteristics and nine NMR biomarkers which could identify ME/CFS with an AUC of 0.83 and recall of 0.70. A multi-variable score was subsequently derived from the same 28 features, which exhibited ~2.5 times greater association than the top individual biomarker.ConclusionsThis study provides an end-to-end analytical workflow that explores the potential clinical utility that association scores may have for ME/CFS and other difficult to diagnose conditions.</p>
7 Authors
- Katherine Huang
- Alex G. C. de Sá
- Natalie Thomas
- Robert D. Phair
- Paul R. Gooley
- David B. Ascher
- Christopher W. Armstrong
1 Application
| Application ID | Title |
|---|---|
| 79568 | Precision medicine for ME/CFS using omics data and machine learning |
Enabling scientific discoveries that improve human health