| Title: | Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort |
| Journal: | Translational Psychiatry |
| Published: | 15 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39548087/ |
| DOI: | https://doi.org/10.1038/s41398-024-03177-3 |
Publication 14297
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Weight-inducing psychotropic treatments are risk factors for age-related diseases such as cardiovascular disorders, which are associated with both inflammation and telomere length shortening. With a longitudinal design, the present study evaluates telomere length trajectories after 1 year of weight-inducing psychotropic medication, accounting for weight changes and the inflammatory biomarker high-sensitivity C-Reactive Protein (CRP). Among 200 patients, an overall median telomere shortening of -41.2 bp was observed (p = 0.014), which is comparable with the general population's yearly telomere attrition. Linear regression showed on average -93.1 and -58.9 bp of further telomere shortening per five units of BMI for BMI values < or ≥30 kg/m2, respectively (p = 0.003 and p = 0.009, respectively). Importantly, the overall telomere shortening was predicted to be increased four-fold among patients with low baseline weight (i.e., 50 kg) and with clinically relevant weight gain (≥ 7%) after 1 year of treatment (interaction term between relevant weight gain and baseline weight: +6.3 bp, p = 0.016). Patients with relevant weight gain showed greater CRP levels (+ 49%; p = 0.016), and a telomere shortening of -36.2 bp (p = 0.010) was estimated whenever CRP level doubled. Mendelian randomization using UKBiobank data showed a causal effect of BMI on telomere shortening, notably stronger among patients receiving weight-inducing psychotropic treatments (n = 9798) than among psychiatric patients without such drugs (n = 16228) and non-psychiatric controls (n = 252932) (beta: -0.37, -0.12, -0.06, respectively; p = 0.004, p < 0.001, p < 0.001, respectively). Ultimately, telomere trajectories were associated with 1 year weight gain and increases in CRP levels, with telomere shortening strongly enhanced by BMI increments among patients receiving weight-inducing psychotropic treatments.</p>
13 Keywords
- Adult
- Aged
- Body Mass Index
- C-Reactive Protein
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Psychotropic Drugs
- Telomere
- Telomere Shortening
- Weight Gain
13 Authors
- Marianna Piras
- Jue Lin
- Marie Catherine Sadler
- Setareh Ranjbar
- Claire Grosu
- Nermine Laaboub
- Martin Preisig
- Franziska Gamma
- Kerstin Jessica Plessen
- Armin von Gunten
- Philippe Conus
- Zoltan Kutalik
- Chin B. Eap
Enabling scientific discoveries that improve human health