| Title: | Prodromal Parkinson's disease and subsequent risk of Parkinson's disease and mortality |
| Journal: | npj Parkinson's Disease |
| Published: | 9 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39779712/ |
| DOI: | https://doi.org/10.1038/s41531-024-00863-3 |
Publication 14542
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Abstract
Association of prodromal Parkinson's disease (PD) with risk of PD and risk of mortality in individuals with PD warrant investigation through large-scale prospective study. We included 501,475 participants without PD at baseline. Eight prodromal features were measured. Incident PD cases were identified via hospital admission, death register, and self-report. Cox regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariable-adjusted HRs3+vs.0 prodromal PD features and 95%CIs were 3.12 (2.58-3.78) for men and 2.71 (2.11-3.47) for women. Prodromal PD predicted only PD onset occurred during the first 6 years of follow-up (HR3+vs.0 prodromal features = 10.5; 95% CI: 8.60-12.9), but not after 6 years (HR = 1.00; 95%CI: 0.76-1.32). The presence of prodromal PD conferred a higher risk of mortality among participants with PD. Having prodromal PD were associated with higher probability of developing PD in short-term and higher risk of mortality among individuals with PD.</p>
5 Authors
- Xiao Chen
- Yaqi Li
- Yun Shen
- Michael A. Schwarzschild
- Xiang Gao
1 Application
| Application ID | Title |
|---|---|
| 96083 | Associations of diet and metabolic profile with risk of cardiometabolic disease and neurodegenerative disease |
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