| Title: | Protective role of apolipoprotein A and B in Parkinson's disease: A prospective study from UK Biobank |
| Journal: | Parkinsonism & Related Disorders |
| Published: | 6 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39798254/ |
| DOI: | https://doi.org/10.1016/j.parkreldis.2025.107266 |
Publication 14564
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Abstract
INTRODUCTION: Evidence have indicated relation between apolipoproteins and neurodegenerative disorders (NDDs). However, previous studies have produced inconsistent results, and a comprehensive analysis of apolipoproteins in NDDs is currently lacking.</p>
METHODS: Using Cox proportional hazards regression analysis based on data from UK Biobank, we examined the association between baseline serum levels of apolipoprotein A (ApoA) and apolipoprotein B (ApoB) and risk of Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and multiple sclerosis.</p>
RESULTS: Elevated baseline levels of serum ApoA (HR = 0.84, 95 % CI: 0.71-0.99, P = 0.047) and ApoB (HR = 0.67, 95 % CI: 0.57-0.78, P = 3.18E-07) were associated with a reduced risk of incident PD. Subgroup analyses suggested the protective effect of serum ApoA was more significant for older participants and those with lower alcohol consumption, while higher serum ApoB was a more significant protective factor in males and those without stroke. No significant associations were found between apolipoproteins and other NDDs.</p>
CONCLUSION: Increased baseline levels of serum ApoA and ApoB are linked to a lower risk of PD. These findings enhance understanding of the role of apolipoproteins in PD, and have implications for the development of therapeutic strategies in clinical trials.</p>
14 Keywords
- Aged
- Apolipoprotein B-100
- Apolipoproteins A
- Apolipoproteins B
- Biological Specimen Banks
- Female
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Prospective Studies
- Protective Factors
- UK Biobank
- United Kingdom
6 Authors
- Shuqi Cao
- Xia Fu
- Wenjing Li
- Peixi Wang
- Chunyu Li
- Huifang Shang
1 Application
| Application ID | Title |
|---|---|
| 98992 | Precision medicine of central nervous system diseases combining demographics, imaging, genetics, and other omics |
Enabling scientific discoveries that improve human health