| Title: | A cohort study of maternal smoking during pregnancy, offspring genetic risk, and overall cancer mortality |
| Journal: | Chinese Journal of Epidemiology |
| Published: | 10 Aug 2024 |
| DOI: | https://doi.org/10.3760/cma.j.cn112338-20240221-00078 |
Publication 14585
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Abstract
Objective To investigate the independent and combined effects of maternal smoking during pregnancy and offspring genetic susceptibility on overall cancer mortality. Methods Based on the United Kingdom Biobank ( n =419 228) data, the Cox proportional hazard regression model was used to estimate the effect of maternal smoking during pregnancy on offspring overall cancer (including 16 cancers in men and 18 in women) mortality and its combined effect and interaction with offspring genetic factors. Results Maternal smoking during pregnancy was significantly associated with a 13% increased risk of overall cancer mortality in men [hazard ratio( HR )=1.13, 95% CI : 1.06-1.20] and 19% increased risk in women ( HR =1.19, 95% CI : 1.11-1.27). Participants with high genetic risk had the highest overall cancer mortality than those with low genetic risk (men: HR =1.42, 95% CI : 1.30-1.55; women: HR =1.38, 95% CI : 1.25-1.52). Compared with participants without maternal smoking during pregnancy and low genetic risk, those with maternal smoking during pregnancy and high genetic risk were associated with a 56% increased risk of overall cancer mortality in men ( HR =1.56, 95% CI : 1.37-1.77) and 59% in women ( HR =1.59, 95% CI : 1.39-1.83). Conclusion Maternal smoking during pregnancy may increase offspring overall cancer mortality and more severe harm in individuals with high genetic risk.</p>
9 Authors
- 庞官连
- 马志敏
- 诸铭轩
- 葛文静
- 牟园淋
- 王国庆
- 朱兆鹏
- 李樵
- 朱猛
1 Application
| Application ID | Title |
|---|---|
| 82535 | Attributable risk of genetic, lifestyle and environmental factors on the incidence and mortality of pan-cancer |
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