| Title: | The fibrosis investigating navigator in diabetes (FIND): A tool to predict liver fibrosis risk in subjects with diabetes |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 5 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39638772/ |
| DOI: | https://doi.org/10.1111/dom.16109 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802394 |
Publication 14675
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Abstract
BACKGROUND: Type 2 diabetes increases the risk of cirrhosis and liver cancer. Noninvasive and early assessment of liver fibrosis is essential. We aimed to develop a score to aid in the initial assessment of liver fibrosis in the diabetic population.</p>
METHODS: A fibrosis investigating navigator in diabetes (FIND) score was developed and validated in the NHANES dataset (2017-2020). Fibrosis was defined as a liver stiffness measurement (LSM) ≥8.0 kPa. The diagnostic accuracies of FIB-4, NFS, LiverRisk, steatosis-associated fibrosis estimator (SAFE) and metabolic dysfunction-associated fibrosis (MAF-5) were compared. FIND was also externally validated in various liver diseases via biopsy as a reference in an Asian centre between 2016 and 2020. Finally, we examined the prognostic implications of the FIND index utilizing data from the UK Biobank cohort (2006-2010).</p>
RESULTS: The FIND score model yielded an AUROC of 0.781 for the prediction of an LSM ≥8 kPa in the validation set, which was consistently greater than that of other available models (all p < 0.05). In the whole NHANES dataset, the 85% sensitivity cut-off of 0.16 corresponded to a NPV of 91.9%, whereas the 85% specificity cut-off of 0.31 corresponded to a PPV of 50.6%. FIND displayed overall accuracies similar to those of the other models in staging fibrosis stages, with biopsy used as a reference. In the UK Biobank cohort, FIND >0.31 was associated with an increased risk of all-cause and liver-related mortality in the diabetic population in adjusted models (HR, 1.75; 95% CI, 1.62-1.89; HR, 23.59; 95% CI, 13.67-40.69).</p>
CONCLUSIONS: In diabetes patients, the novel FIND score performs well in identifying subjects at risk of liver fibrosis and predicting all-cause and liver-related mortality.</p>
14 Keywords
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Elasticity Imaging Techniques
- Female
- Humans
- Liver Cirrhosis
- Male
- Middle Aged
- Nutrition Surveys
- Predictive Value of Tests
- Prognosis
- Risk Assessment
- Risk Factors
6 Authors
- Mingkai Li
- Hongsheng Yu
- Sizhe Wan
- Fulan Hu
- Qingtian Luo
- Wei Gong
1 Application
| Application ID | Title |
|---|---|
| 81680 | Identifying risk factors for chronic diseases and multimorbidity in UK Biobank: a longitudinal cohort study |
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