| Title: | Cardiovascular health and risks of atrial fibrillation and its prognosis |
| Journal: | American Journal of Preventive Cardiology |
| Published: | 12 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39807446/ |
| DOI: | https://doi.org/10.1016/j.ajpc.2024.100915 |
Publication 14712
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Abstract
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia around the world with an increased risk of a broad spectrum of adverse comorbidities and death. Whether cardiovascular health (CVH) is associated with AF development remains unclear.</p>
Methods: 238,420 participants without cardiovascular disease at baseline were selected from the UK Biobank study cohort from 2006 to 2010. CVH was defined based on "Life's Essential 8″ scores. Sex-specific multi-state Markov and flexible parametric survival models were used to estimate the hazard ratio (HR) and 95 % confidence intervals (95 % CI) for the associations of CVH with incident AF and its prognosis.</p>
Results: In fully-adjusted models, CVH is significantly associated with a reduced risk of incident AF among both men and women, after accounting for the potential impact of death. Among AF patients without other evaluated diseases, a higher CVH score was generally linked with a reduced risk of death in both sexes. Among AF patients with incident prognostic diseases, only CVH associated with death following heart failure (0.78, 0.63-0.97) was observed among men, whereas CVH was significantly associated with death following coronary heart disease (0.80, 0.69-0.93), stroke (0.73, 0.61-0.89) and dementia (0.79, 0.71-1.03) among women.</p>
Conclusions: We found significant associations between CVH and the risk reduction of incident AF and its prognostic outcomes, with these associations being more pronounced among women. Findings suggest a potential of screening CVH for both primary prevention of new-onset AF and the secondary prevention to improve AF prognosis.</p>
7 Authors
- Zuolin Lu
- Jiawen Ke
- Hongxi Yang
- Xiaoxuan Zhang
- Yachen Wang
- Yabing Hou
- Ruitai Shao
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