| Title: | Associations between genetic variations in oxytocin pathway genes and hippocampal volume: Insights from the UK Biobank |
| Journal: | Cortex |
| Published: | 17 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39736190/ |
| DOI: | https://doi.org/10.1016/j.cortex.2024.11.017 |
Publication 14737
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The role of oxytocin-related genes in social-cognitive function has been previously established, but structural brain mechanisms underlying this link remain poorly understood. Utilizing a substantial dataset from the UK Biobank (N ≈ 30,000), this research determined associations between variations in ten single nucleotide polymorphisms (SNPs) within three oxytocin pathway genes (i.e., the oxytocin/neurophysin I prepropetide gene, the cluster of differentiation 38 glycoprotein gene, the oxytocin receptor gene) and whole-brain gray matter volume. Carriers of the AA or AG genotypes of the oxytocin receptor gene rs237851 SNP exhibited significantly larger hippocampal volume than carriers of the GG genotype. These results support the link between variations in the oxytocin receptor gene and hippocampal structure, with possible impact on social-cognitive function such as social recognition memory.</p>
17 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Female
- Genetic Variation
- Genotype
- Gray Matter
- Hippocampus
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Oxytocin
- Polymorphism, Single Nucleotide
- Receptors, Oxytocin
- UK Biobank
- United Kingdom
7 Authors
- Shanshan Xiao
- Natalie C Ebner
- Junhua Dang
- Gull Rukh
- Lars Westberg
- Helgi B Schiöth
- Håkan Fischer
1 Application
| Application ID | Title |
|---|---|
| 30172 | Comorbidities between addiction and mental disorders ? association of genetics, biomarkers and environment (e.g. lifestyle) with mental health and cognitive function |
Enabling scientific discoveries that improve human health