| Title: | Association between accelerometer-measured irregular sleep duration and longitudinal changes in body mass index in older adults |
| Journal: | International Journal of Obesity |
| Published: | 6 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40189712/ |
| DOI: | https://doi.org/10.1038/s41366-025-01768-8 |
| URL: | https://doi.org/10.1101/2024.10.30.24316315 |
Publication 14745
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Abstract
BackgroundIrregular sleep duration may disrupt circadian rhythms and contribute to metabolic, behavioral, and mood changes, potentially increasing the risk for obesity. However, quantitative data on the relationship between sleep duration irregularity and weight change are lacking.MethodsIn this prospective study, we analyzed data from 10,572 participants (mean age: 63 years) in the UK Biobank who wore accelerometers for a week between 2013 and 2015 and had two body mass index (BMI; kg/m²) measurements on average 2.5 years apart. Irregular sleep duration was assessed by the within-person standard deviation (SD) of 7-night accelerometer-measured sleep duration.ResultsParticipants with sleep duration SD > 60 min versus ≤30 min had 0.24 kg/m2 (95% CI: 0.08, 0.40) higher BMI change (kg/m2), standardized to three-year intervals, and 80% (95% CI: 1.28, 2.52) higher risk for incident obesity, after adjusting for sociodemographic factors, shift work, and baseline BMI or follow-up period (p-nonlinearity <0.02 for both). These associations remained consistent after adjusting for lifestyle, comorbidities, and other sleep factors, including sleep duration. Age, sex, baseline BMI, and genetic predisposition to higher BMI (measured with a polygenic risk score) did not appear to modify the association.ConclusionsSince irregular sleep duration is common, trials of interventions targeting sleep irregularity might lead to new public health strategies that tackle obesity.</p>
8 Authors
- Sina Kianersi
- Kaitlin S. Potts
- Heming Wang
- Tamar Sofer
- Raymond Noordam
- Martin K. Rutter
- Susan Redline
- Tianyi Huang
1 Application
| Application ID | Title |
|---|---|
| 85501 | Elucidating risk factors for and health impact of heart, lung, blood, and sleep disorders |
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