| Title: | Association between sleep and ALS-FTSD: A Prospective Cohort Study based on 396,918 UK biobank participants |
| Journal: | Translational Psychiatry |
| Published: | 4 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40185700/ |
| DOI: | https://doi.org/10.1038/s41398-025-03328-0 |
Publication 14764
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Abstract
Amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) is a fatal neurodegenerative condition, and identifying its modifiable risk factors is a critical public health issue. This large-scale prospective cohort study investigated the role of sleep-related factors in ALS-FTSD risk using data from 396,918 UK Biobank participants. Eight sleep-related exposures were assessed, and Cox proportional hazards regression was employed to evaluate their associations with ALS-FTSD incidence. Subgroup and sensitivity analyses were conducted to validate the robustness of our findings. At baseline, participants had a mean age of 56.31 ± 8.12 years, with 47.5% being male. In the fully adjusted Cox model, organic sleep disorders (G47) (HR: 1.81, 95% CI: 1.21, 2.72, P = 0.004), hypersomnia (G47.1) (HR: 36.53, 95% CI: 9.04, 147.55, P < 0.001), and extreme short sleep (<5 h per day) (HR: 2.09, 95% CI: 1.09, 3.99, P = 0.046) were significantly associated with increased ALS-FTSD risk. In conclusions, these findings revealed the relationship between sleep and the risk of ALS-FTSD, identifying new modifiable risk factors and potential preventive possibilities for ALS-FTSD. Further research is warranted to elucidate the mechanistic links between sleep disturbances and ALS-FTSD pathogenesis.</p>
17 Keywords
- Adult
- Aged
- Amyotrophic Lateral Sclerosis
- Biological Specimen Banks
- Female
- Frontotemporal Dementia
- Humans
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sleep
- Sleep Wake Disorders
- UK Biobank
- United Kingdom
16 Authors
- Tianmi Yang
- Dejiang Pang
- Jingxuan Huang
- Yi Xiao
- Chunyu Li
- Qianqian Wei
- Ruwei Ou
- Yangfan Cheng
- Junyu Lin
- Ningning Che
- Jiajia Fu
- Qirui Jiang
- Shichan Wang
- Jiyong Liu
- Sirui Zhang
- Huifang Shang
1 Application
| Application ID | Title |
|---|---|
| 98992 | Precision medicine of central nervous system diseases combining demographics, imaging, genetics, and other omics |
Enabling scientific discoveries that improve human health