| Title: | Plasma β-hydroxybutyrate concentration, genetic risk, and the incidence of Alzheimer's disease: A prospective study of 261,933 participants |
| Journal: | Clinical Nutrition |
| Published: | 7 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39854811/ |
| DOI: | https://doi.org/10.1016/j.clnu.2025.01.007 |
Publication 14872
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Abstract
BACKGROUND: We investigated whether plasma β-hydroxybutyrate levels, a genetic risk score for Alzheimer's disease, and their interaction are associated with incident Alzheimer's disease.</p>
METHODS: Using data from the UK Biobank-a population-based cohort study of adults aged 40-69 years, we assessed associations between baseline plasma β-hydroxybutyrate level, genetic risk score for Alzheimer's disease, and incident Alzheimer's disease. Incident Alzheimer's disease data were collected through linked data from hospital admissions and death registries.</p>
RESULTS: In total, 261,933 adults were included, 1978 of whom developed incident Alzheimer's disease. Plasma β-hydroxybutyrate concentrations were not independently associated with Alzheimer's disease incidence after adjusting for covariates, whereas a higher genetic predisposition was linked to increased Alzheimer's disease incidence. Interactions were observed between plasma β-hydroxybutyrate concentrations and genetic risk for Alzheimer's disease on Alzheimer's disease incidence (P < 0.001).</p>
CONCLUSIONS: Further studies are warranted to elucidate the impact of plasma β-hydroxybutyrate status on Alzheimer's disease incidence.</p>
13 Keywords
- 3-Hydroxybutyric Acid
- Adult
- Aged
- Alzheimer Disease
- Female
- Genetic Predisposition to Disease
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
4 Authors
- Ha-Na Kim
- Ji Hyun Lee
- John Boscardin
- John C Newman
1 Application
| Application ID | Title |
|---|---|
| 87759 | Regulation of age-related diseases by cellular metabolites |
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