| Title: | Clonal Hematopoiesis of Indeterminate Potential as a Predictor of Colorectal Cancer Risk: Insights from the UK Biobank Cohort. |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 13 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39804050/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-24-1342 |
Publication 14891
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence of solid tumors, but its relationship with colorectal cancer still needs to be studied.</p>
METHODS: We conducted a prospective matched case-control study using data from the UK Biobank, including 5,310 incident colorectal cancer cases and 26,550 controls matched for age, sex, and body mass index.</p>
RESULTS: Analysis of the UK Biobank data revealed that the presence of CHIP was associated with an increased risk of colorectal cancer. The odds ratio (OR) for colorectal cancer in the presence of CHIP was 1.20 (P = 0.006). This association remained significant even after excluding participants with a family history of bowel cancer (multivariate OR, 1.19; P = 0.007). Subgroup analyses demonstrated that CHIP independently increased the risk of colorectal cancer in females (multivariate OR, 1.25; P = 0.018) and in individuals older than 60 years (multivariate OR, 1.17; P = 0.046). Gene-specific analyses revealed that mutations in TET2 and ATM were particularly significant in relation to colorectal cancer risk, with an OR of 1.62 (P = 0.002) for TET2 and 2.98 (P < 0.001) for ATM.</p>
CONCLUSIONS: Our findings indicate that CHIP is associated with an increased risk of colorectal cancer, particularly in individuals more than 60 years of age or in females.</p>
IMPACT: Screening for CHIP in the population may improve the early detection and diagnosis rates of colorectal cancer.</p>
16 Keywords
- Aged
- Ataxia Telangiectasia Mutated Proteins
- Biological Specimen Banks
- Case-Control Studies
- Clonal Hematopoiesis
- Colorectal Neoplasms
- DNA-Binding Proteins
- Dioxygenases
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- UK Biobank
- United Kingdom
10 Authors
- Yongfeng Liu
- Zhihui Xi
- Jianlong Zhou
- Fa Ling
- Yucheng Zhang
- Huajie Xie
- Jiabin Zheng
- Baijin Xia
- Huolun Feng
- Yong Li
1 Application
| Application ID | Title |
|---|---|
| 98937 | Shared and distinct mechanisms between mental disorders and noncommunicable chronic diseases: prevention, risk prediction and precision treatment |
Enabling scientific discoveries that improve human health